Our UHN programs and services are among the most advanced in the world. We have grouped our physicians, staff, services and resources into 10 medical programs to meet the needs of our patients and help us make the most of our resources.
University Health Network is a health care and medical research organization in Toronto, Ontario, Canada. The scope of research and complexity of cases at UHN has made us a national and international source for discovery, education and patient care.
Our 10 medical programs are spread across eight hospital sites – Princess Margaret, Toronto General, Toronto Rehab’s five sites, Toronto Western – as well as our education programs through the Michener Institute of Education at UHN. Learn more about the services, programs and amenities offered at each location.
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Behind the Breakthrough enters its fourth season of showcasing groundbreaking medical research and people behind it at UHN. This season features an all-star cast of award winning scientists, including Scientist Emerita Dr. Eleanor Fish whose research into a naturally occurring protein in our bodies called interferons shows they are a highly effective therapeutic for the treatment of viruses, and Dr. Shaf Keshavjee and the story of how he invented a perfusion machine that can sustain and repair damaged lungs outside the body, making them healthy for transplantation.
Listeners will hear world-renowned stem cell scientist Dr. Gordon Keller reveal how his early years growing up on a mixed farm in rural Saskatchewan and returning to help his parents with the fall harvest throughout his undergrad years helped shape his work ethic in the lab. Dr. Lorraine Kalia trained for years with Canada's National Ballet School and rose to the corps de ballet of the National Ballet of Portugal before pivoting her career to the pursuit of an early intervention treatment for Parkinson's disease. And Dr Jonathan Irish speaks to how he was a five-time provincial canoeing champion on a path to competing for Canada at the Olympic Games when he decided helping patients conquer cancer was to be his chosen path.
Listen for new episodes of
Behind the Breakthrough every Wednesday starting October 12.
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Episode 8 – Dr. Rama Khokha on her breakthrough to map the biology of pancreatic cancer
Air Date: November 30, 2022 | Length: 34:50 | Download the transcript
Pancreatic cancer is an aggressive cancer with poor survival rates. Huge contributors to the dire outcome is the fact it is typically diagnosed at an advanced stage, has only limited treatments, and no cure. This is what makes the recent breakthrough discovery of Dr. Rama Khokha and her lab so profound. In this episode of
Behind the Breakthrough podcast, the UHN senior scientist at the Princess Margaret Cancer Centre walks us through her recent world-first discovery of successfully mapping the biology of a pancreatic cancer tumor. Dr. Khokha found three distinct tumour microenvironments [TME's] for pancreatic cancer – Resistant; Deserted; and Intermediate. The Resistant TME for example was found to be the most aggressive, while the Deserted MTE was found to resist – and grow – during chemotherapy.
Dr. Khokha's mapping now gives researchers a clear understanding of the behaviour of pancreatic cancer. And her discovery will have far-reaching impact – contributing to more research for precise new treatments, the potential for earlier diagnosis, as well applying her mapping technique to other cancers such as colorectal and lung cancer.
Dr. Khokha also speaks to her drive to make discoveries where there is unmet need in cancer research, including breast cancer prevention and new treatment and prevention of osteosarcoma – the cancer Terry Fox had.
Also in the podcast, Dr. Khokha talks about the qualities she believes are integral to a successful medical researcher, the emergence of her love of science while growing up in Delhi, India, and, setting out on her own at just 21 years of age to start anew in Canada to follow her dream - the pursuit a PhD and becoming a world-class medical researcher.
Listen to the full episode and subscribe wherever you get your podcasts.
Episode 7 – Dr. Lorraine Kalia and a promising new treatment for Parkinson's DiseaseAir Date: November 23, 2022 | Length: 41:54
Learn more about Dr. Kalia & listen to the episode
Episode 6 – Dr. Eleanor Fish on therapeutic benefit of interferons against virusesAir Date: November 16, 2022 | Length: 31:49
Learn more about Dr. Fish & listen to the episode
Episode 5 – Dr. Jonathan Irish and augmented reality in cancer surgeryAir Date: November 9, 2022 | Length: 46:54
Learn more about Dr. Irish & listen to the episode
Episode 4 – Dr. Carmela Tartaglia and pioneering a diagnosis for CTEAir Date: November 2, 2022 | Length: 43:57
Learn more about Dr. Tartaglia & listen to the episode
Episode 3 – Dr. Andrea Iaboni and a new toolkit for LTC to help care of residents during an outbreakAir Date: October 26, 2022 | Length: 33:56
Learn more about Dr. Iaboni & listen to the episode
Episode 2 – Dr. Gordon Keller on his groundbreaking research to advance stem cell-based therapiesAir Date: October 19, 2022 | Length: 43:23
Learn more about Dr. Keller & listen to the episode
Episode 1 – Dr. Andrea Furlan on groundbreaking new treatments for chronic painAir Date: October 12, 2022 | Length: 1:01:41
Learn more about Dr. Furlan & listen to the episode
Episode 10 – Dr. Angela Cheung pioneers research on the symptoms and treatment for long-hauler COVID patientsAir Date: December 14, 2021 | Length: 40:56
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Episode 9 – Dr. Andres Lozano on investigating DBS to treat Alzheimer's diseaseAir Date: December 7, 2021 | Length: 38:35
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Episode 8 – Dr. Babak Taati on pioneering the use of computer vision to help seniors live safer, healthier lives Air Date: November 30, 2021 | Length: 34:36
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Episode 7 – The 'Biomarker Hunter' – searching for the genetic and immune system abnormalities that lead to systemic autoimmune rheumatic diseases Air Date: November 23, 2021 | Length: 37:58
Learn more about Dr. Wither & listen to the episode
Episode 6 – Dr. Gang Zheng on harnessing the promise of nanotechnology for the detection and treatment of cancer Air Date: November 16, 2021 | Length: 52:10
Learn more about Dr. Zheng & listen to the episode
Episode 5 – Dr. Jordan Feld on shifting from discovering a pill that cures Hepatitis C to investigating a treatment for mild COVID Air Date: November 9, 2021 | Length: 53:10
Learn more about Dr. Feld & listen to the episode
Episode 4 – Dr. Catherine O'Brien on the world-first discovery that colorectal cancer cells hibernate like bears to evade chemotherapy Air Date: November 2, 2021 | Length: 44:44
Learn more about Dr. O'Brien & listen to the episode
Episode 3 – Dr. Deepali Kumar on world-first discovery that third COVID-19 vaccine dose significantly boosts protection for transplant patients Air Date: October 26, 2021 | Length: 28:05
Learn more about Dr. Kumar & listen to the episode
Episode 2 – Dr. Beate Sander on the economics of infectious diseases and guiding public health policy during the COVID-19 pandemic Air Date: October 19, 2021 | Length: 47:21
Learn more about Dr. Sander & listen to the episode
Episode 1 – UHN's world leading COVID-19 research; the triumph of basic science in creating the vaccine; and when will the pandemic end? Air Date: October 12, 2021 | Length: 54:52
Learn more about Dr. Wouters & listen to the episode
Episode 10 – Dr. John Dick on his famous discovery of cancer stem cells, and the puzzle of research Air Date: November 26, 2020 | Length: 1:15:06
Learn more about Dr. Dick & listen to the episode
Episode 9 — Dr. Mansoor Husain on a breakthrough drug for diabetes and heart disease Air Date: | Length:
Episode 8 – Dr. Alex Mihailidis on helping us live at home longer Air Date: November 19, 2020 | Length: 45:02
Learn more about Dr. Mihailidis & listen to the episode
Episode 7 – Dr. Ralph DaCosta on a better way to visualize cancer and his serendipitous invention Air Date: November 17, 2020 | Length: 41:48
Learn more about Dr. DaCosta & listen to the episode
Episode 6 – Dr. Sonya MacParland on developing the world's first map of the liver Air Date: November 12, 2020 | Length: 42:52
Episode 5 – Dr. Heather Baltzer on pioneering hand trauma treatment Air Date: November 10, 2020 | Length: 31:26
Learn more about Dr. Baltzer & listen to the episode
Episode 4 – Dr. Pamela Ohashi on treating cancer with immunotherapy Air Date: November 5, 2020 | Length: 28:05
Learn more about Dr. Ohashi & listen to the episode
Episode 3 – Dr. Taufik Valiante invents computer chip designed to monitor and stop epileptic seizures Air Date: November 3, 2020 | Length: 52:27
Learn more about Dr. Valiante & listen to the episode
Episode 2 – Turning stem cells into pacemaker cells, with Dr. Stephanie Protze Air Date: October 29, 2019 | Length: 30:27
Learn more about Dr. Protze & listen to the episode
Episode 1 – Dr. Brad Wouters on leadership during the pandemic, COVID-19 research, and anti-vaxxers Air Date: October 27, 2020 | Length: 46:35
Episode 11 – Beating back Alzheimer's, one poem at a time, with Dr. Donald Weaver Air Date: December 17, 2019 | Length: 37:14
Learn more about Dr. Weaver & listen to the episode
Episode 10 — Using computers to understand cancer with Dr. Michael Hoffman Air Date: December 10, 2019 | Length: 31:00
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Episode 9 — Pioneering research by UHN's Dr. Kristin Musselman is designed to get spinal cord injured patients mobile Air Date: December 3, 2019 | Length: 30:22
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Episode 8 — Reversing blindness and the serendipity of science, with Dr. Valerie Wallace Air Date: November 26, 2019 | Length: 35:04
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Episode 7 – Repairing broken hearts with stem cells, with Dr. Michael Laflamme Air Date: November 19, 2019 | Length: 28:22
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Episode 6 – Overcoming 'imposter syndrome' and helping the elderly live well, with Dr. Jennifer Campos Air Date: November 12, 2019 | Length: 40:02
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Episode 5 – Meet the cancer codebreaker, Dr. Mathieu Lupien Air Date: November 5, 2019 | Length: 47:38
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Episode 4 – Robotics, rehabilitation therapy and learning from failure, with Dr. Milos Popovic Air Date: October 29, 2019 | Length: 32:03
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Episode 3 – Challenging the meaning of palliative care, with Dr. Camilla Zimmermann Air Date: October 22, 2019 | Length: 43:20
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Episode 2 – Chronic pain and scientific baseball, with Dr. Karen Davis Air Date: October 15, 2019 | Length: 34:56
Learn more about Dr. Davis & listen to the episode
Episode 1 – Dr. Heather Ross on heart failure, artificial intelligence and a near-death experience Air Date: October 8, 2019 | Length: 42:07
Learn more about Dr. Ross & listen to the episode