Our UHN programs and services are among the most advanced in the world. We have grouped our physicians, staff, services and resources into 10 medical programs to meet the needs of our patients and help us make the most of our resources.
University Health Network is a health care and medical research organization in Toronto, Ontario, Canada. The scope of research and complexity of cases at UHN has made us a national and international source for discovery, education and patient care.
Our 10 medical programs are spread across eight hospital sites – Princess Margaret, Toronto General, Toronto Rehab’s five sites, Toronto Western – as well as our education programs through the Michener Institute of Education at UHN. Learn more about the services, programs and amenities offered at each location.
Maps & Directions
Find out how to get to and around our nine locations — floor plans, parking, public transit, accessibility services, and shuttle information.
Ways You Can Help
Being touched by illness affects us in different ways. Many people want to give back to the community and help others. At UHN, we welcome your contribution and offer different ways you can help so you can find one that suits you.
The Newsroom is the source for media looking for information about UHN or trying to connect with one of our experts for an interview. It’s also the place to find UHN media policies and catch up on our news stories, videos, media releases, podcasts and more.
Toronto (Nov. 24, 2007) - Cancer specialists and researchers at Princess Margaret Hospital, University Health Network (UHN), are tackling an ongoing controversy about the best way to treat an aggressive form of bladder cancer – immediate radical surgery or a more conservative initial approach using immunotherapy?
To answer that question, Drs. Girish Kulkarni, Shabbir Alibhai and colleagues calculated the life expectancy and the quality of life expected from the two treatment methods. The team used a decision-analysis tool – the Markov model – a first for this form of bladder cancer.
The results will be released Sept. 25 in PloS Medicine, the journal of the Public Library of Science, which is a peer-reviewed, open-access journal that publishes original research relevant to improving human health.
Cystectomy – the surgical removal of the bladder – is considered an excellent treatment to cure this form of bladder cancer. In some cases, a new bladder is fashioned from part of the bowel. In others, an opening is created to collect urine in a pouch outside the body. Immunotherapy uses bacillus Calmette-Guerin (BCG; the tuberculosis bacterium) to treat cancer cells directly in the bladder and avoids the need for a major operation. BCG stimulates an immune response that diminishes the risk of tumour recurrence and/or progression. The researchers compared the pros and cons of each treatment in their model.
The findings demonstrate that patients under the age of 60 who opt for immediate surgery can live longer with a higher quality of life than if they had chosen the more conservative option. On the other hand, the better choice for patients over age 70 with other health issues – or for those who place a high value on retaining sexual function and avoiding other side effects of surgery that may impair quality of life – was the more conservative initial approach using immunotherapy.
More importantly, the study identified the major quality of life factors that should be discussed with patients when choosing between these treatment options.
"Our findings highlight the trade-off that exists when deciding between radical surgery and a more conservative approach to treating this pre-invasive form of bladder cancer. The results of this study should help urologists to discuss the balance between quantity and quality of life, particularly with patients aged 60 to 70 years," says PMH surgical oncologist Dr. Antonio Finelli, a co-investigator in the study.
"What may appear to be the most suitable treatment initially may not be the case when you consider other health issues and how well an individual will cope with effects of surgery that reduce their quality of life."
The research was supported in part by the Canadian Institutes of Health Research and the National Cancer Institute of Canada.
Princess Margaret Hospital and its research arm, Ontario Cancer Institute, have achieved an international reputation as global leaders in the fight against cancer. Princess Margaret Hospital is a member of the University Health Network, which also includes Toronto General Hospital and Toronto Western Hospital. All three are research hospitals affiliated with the University of Toronto.
Phone: 416 340 4636