Our UHN programs and services are among the most advanced in the world. We have grouped our physicians, staff, services and resources into 10 medical programs to meet the needs of our patients and help us make the most of our resources.
University Health Network is a health care and medical research organization in Toronto, Ontario, Canada. The scope of research and complexity of cases at UHN has made us a national and international source for discovery, education and patient care.
Our 10 medical programs are spread across eight hospital sites – Princess Margaret, Toronto General, Toronto Rehab’s five sites, Toronto Western – as well as our education programs through the Michener Institute of Education at UHN. Learn more about the services, programs and amenities offered at each location.
Maps & Directions
Find out how to get to and around our nine locations — floor plans, parking, public transit, accessibility services, and shuttle information.
Ways You Can Help
Being touched by illness affects us in different ways. Many people want to give back to the community and help others. At UHN, we welcome your contribution and offer different ways you can help so you can find one that suits you.
The Newsroom is the source for media looking for information about UHN or trying to connect with one of our experts for an interview. It’s also the place to find UHN media policies and catch up on our news stories, videos, media releases, podcasts and more.
Toronto (Dec. 22, 2020) - Three clinical trial platforms working together to test the effects of full doses of anticoagulants (blood thinners) in COVID-19 patients have paused enrollment for one group of patients. Among critically ill COVID-19 patients requiring intensive care unit (ICU) support, full dose anticoagulation drugs did not improve outcomes. Enrollment continues for moderately ill hospitalized COVID-19 patients in the trials.
As is normal for clinical trials, these trials are overseen by independent boards that routinely review the data and are composed of experts in ethics, biostatistics, clinical trials, and blood clotting disorders. Informed by the deliberations of these oversight boards, all of the trial sites have paused enrollment of the most critically ill hospitalized patients with COVID-19. A potential for harm in this sub-group could not be excluded. Increased bleeding is a known complication of full-dose anticoagulation. The trials are working urgently to undertake additional analyses which will be made available as soon as possible.
At the recommendation of the oversight boards patients who do not require ICU care at the time of enrollment will continue to be enrolled in the trial. Whether the use of full-dose compared to low-dose blood thinners leads to better outcomes in hospitalized patients with less severe disease remains a very important question.
COVID-19 is associated with significant inflammation and clinical and pathologic evidence of widespread blood clots. These trials were launched because clinicians have observed that many patients ill with COVID-19, including those who have died from the disease, formed blood clots throughout their bodies, even in their smallest blood vessels. This unusual clotting can cause multiple health complications, including lung failure, heart attack, and stroke.
"In only our most critically ill patients with COVID-19, all of our trial sites have paused enrollment while we further analyze the data. These results question the benefit of giving full dose anticoagulants routinely in COVID-19 patients who are admitted to an ICU," said Ryan Zarychanski, M.D., M.Sc., Israels associate professor of medicine at the University of Manitoba and CancerCare Manitoba in Canada, a hematologist and critical care physician, who led the harmonization of the three trials.
The multiple platform randomized controlled trial (mpRCT) represents an unprecedented collaboration between three international partners. The Randomized, Embedded, Multi-factorial Adaptive Platform Trial for Community-Acquired Pneumonia (REMAP-CAP) Therapeutic Anticoagulation; Accelerating COVID-19 Therapeutic Interventions and Vaccines-4 (ACTIV-4) Antithrombotics Inpatient; and Antithrombotic Therapy to Ameliorate Complications of COVID-19 (ATTACC) are a set of clinical trial platforms spanning five continents with the common goal of testing whether there is a benefit of full doses of blood thinners to treat adults hospitalized for COVID-19 illness on the ward or in the ICU compared to the lower dose used to prevent blood clots in hospitalized patients. To meet the challenge of this pandemic, investigators worldwide joined forces to answer this question as rapidly as possible.
"These results represent an immense collaborative effort involving patients, clinicians, and research staff around the world enabling us to rapidly learn how best to treat Covid-19," says Ewan Goligher, MD, PhD, assistant professor of medicine, University of Toronto and scientist, Toronto General Hospital Research Institute, University Health Network, and critical care physician. "The strength of the multiplatform clinical trial design enables us to pause in one subset and continue parts of the study."
The trials are supported by multiple international funding organizations including Canadian Institutes of Health Research (CAN), National Institutes of Health Research (UK), National Health and Medical Research Council (AUS) and the National Institutes of Health (US) and the PREPARE and RECOVER consortia (EU).
In Canada, the collaboration was funded by Canadian Institutes of Health Research, LifeArc Foundation, Research Manitoba, Thistledown Foundation, Province of Ontario and the Peter Munk Cardiac Centre at UHN.
About University Health Network University Health Network consists of Toronto General, recently voted one of the Top 10 Hospitals in the World according to Newsweek Magazine, and Toronto Western Hospital, the Princess Margaret Cancer Centre, Toronto Rehabilitation Institute, and the Michener Institute of Education at UHN. The scope of research and complexity of cases at University Health Network has made it a national and international source of discovery, education and patient care. It has the largest hospital-based research program in Canada, with major research in cardiology, transplantation, neurosciences, oncology, surgical innovation, infectious diseases, genomic medicine and rehabilitation medicine. University Health Network is a research hospital affiliated with the University of Toronto.
For media inquiries, please contact:
Senior Public Affairs Advisor
Phone: 416 340 3895