Our UHN programs and services are among the most advanced in the world. We have grouped our physicians, staff, services and resources into 10 medical programs to meet the needs of our patients and help us make the most of our resources.
University Health Network is a health care and medical research organization in Toronto, Ontario, Canada. The scope of research and complexity of cases at UHN has made us a national and international source for discovery, education and patient care.
Our 10 medical programs are spread across eight hospital sites – Princess Margaret, Toronto General, Toronto Rehab’s five sites, Toronto Western – as well as our education programs through the Michener Institute of Education at UHN. Learn more about the services, programs and amenities offered at each location.
Maps & Directions
Find out how to get to and around our nine locations — floor plans, parking, public transit, accessibility services, and shuttle information.
Ways You Can Help
Being touched by illness affects us in different ways. Many people want to give back to the community and help others. At UHN, we welcome your contribution and offer different ways you can help so you can find one that suits you.
The Newsroom is the source for media looking for information about UHN or trying to connect with one of our experts for an interview. It’s also the place to find UHN media policies and catch up on our news stories, videos, media releases, podcasts and more.
Finding the clues to diseases such as lupus and kidney disease is one of the most complicated research puzzles for modern medicine. But Dr. Joan Wither and her research team intend to meet that challenge head-on.
It can be a mouthful simply to explain the groundbreaking research that Dr. Wither, a Senior Scientist at the Krembil Research Institute, and a rheumatologist in the Arthritis Program at Toronto Western Hospital, is conducting.
Her research program focuses on identifying the genetic and immune system abnormalities that lead to systemic autoimmune rheumatic diseases (SARD), including systemic lupus erythematosus (SLE), Sjögren's syndrome and scleroderma.
Dr. Wither is hunting for biomarkers for these diseases, which are related. A biomarker is exactly what it sounds like – a measurable substance in a person, or any organism, that indicates some sort of change such as an infection or a disease.
Her SARD research has four goals, the first of which is to identify biomarkers for the early identification of patients at risk of developing SARD. Dr. Wither is also looking to evaluate therapies for prevention and to map and understand the immune mechanisms that lead to "flares" in autoimmune diseases and their progression, so there can be better diagnosis and treatment for every patient's disease.
Finally, she says, it's important to develop diagnostic tests using biomarkers to monitor how SARD progresses and anticipate when it leads to more severe problems, such as renal (kidney) disease.
Dr. Wither is looking at people with antinuclear antibodies, antibodies that bind to the nucleus of cells.
We all have antibodies in our blood, preventing us from getting sick or minimizing illness. Sometimes antibodies develop that work against our own bodies to trigger an autoimmune reaction that can damage our organs, such as the antinuclear antibodies that are found in SARD. The amount and pattern of these antibodies can be tested through an antinuclear antibody (ANA) test.
Some people have abnormal levels of these antibodies.
"We focus on the patients who have positive ANA tests," Dr. Wither explains.
The Krembil Research Institute and the Globe and Mail have teamed up for a special project designed to highlight the tremendous achievements of the science and research programs at Krembil. The first of three magazines in this series looks at the brain and spine program, a second highlights the vision program and a final edition, which is also now available on line, explores the arthritis program.