Advisory: Give yourself extra time when travelling by car to Toronto General Hospital, Princess Margaret Cancer Centre, or Toronto Rehab University Centre. City of Toronto construction on University Ave. may cause delays.
At UHN, we strive to deliver Compassionate Care & Caring. Learn more about the services and supports that are available to you throughout your journey.
Our UHN programs and services are among the most advanced in the world. We have grouped our physicians,
staff, services and resources into 10 medical programs to meet the needs of our patients and help us make
the most of our resources.
At the heart of everything we do at UHN are our Healthcare Professionals. Refer a patient to one of our 12 medical programs. Learn more about the resources and opportunities available for professional growth.
University Health Network has grown to be one of the largest research and teaching hospital networks in Canada - pioneers in improving the lives of patients. Our long history of health professions education at Toronto General, Toronto Western, Princess Margaret and Toronto Rehab hospitals has consistently advanced the science of education.
University Health Network is a health care and medical research organization in
Toronto, Ontario, Canada. The scope of research and complexity of cases at UHN has made us a national and international
source for discovery, education and patient care.
Being touched by illness affects us in different ways. Many people want to give back to the community
and help others. At UHN, we welcome your contribution and offer different ways you can help so you can find one that suits you.
The Newsroom is the source for media looking for information about UHN or trying to connect with one
of our experts for an interview. It's also the place to find UHN media policies and catch up on our news stories, videos, media releases,
podcasts and more.
A study from the Krembil Research Institute reveals a new possible target for the treatment of a broad family of eye diseases, known as inherited retinal degenerations (IRDs).
IRDs, which affect up to one in 2,000 individuals, are characterized by progressive vision loss that can lead to blindness. Presently, there are neither cures for IRDs, nor treatments that can slow or stop disease progression.
Visual impairment in patients with IRDs is caused by the gradual loss of photoreceptors, which are the cells in the eye that initiate vision.
"Photoreceptors contain a protein known as neogenin," says Dr. Philippe Monnier, Krembil Senior Scientist, who led the study. "We knew that neogenin acts as a major trigger of cell death in several other eye pathologies, so we decided to investigate whether the protein influences photoreceptor survival in IRDs."
The researchers found that neogenin levels are higher in eye tissues from experimental models of IRDs. Neogenin levels were also shown to be higher in the eyes of people living with an IRD. Next, the researchers showed that inhibiting the activity of neogenin in the IRD models prevented the loss of photoreceptors and preserved visual function.
"Our findings suggest that neogenin could be a novel target for protecting the eyesight of people diagnosed with an IRD by promoting the survival of photoreceptors," says Dr. Monnier.
"This work would not have been possible without the generosity of our philanthropic supporters, namely Don and Nita Reed and the Krembil Family. We are very grateful for their continuous support over the years and enthusiasm for vision research."
This work was supported by the Krembil Foundation, Fighting Blindness Canada, Brain Canada, the National Institutes of Health, the National Eye Institute, the Cleveland Clinic Foundation, the University of Toronto and the Toronto General & Western Hospital Foundation.