Advisory: Give yourself extra time when travelling by car to Toronto General Hospital, Princess Margaret Cancer Centre, or Toronto Rehab University Centre. City of Toronto construction on University Ave. may cause delays.
At UHN, we strive to deliver Compassionate Care & Caring. Learn more about the services and supports that are available to you throughout your journey.
Our UHN programs and services are among the most advanced in the world. We have grouped our physicians,
staff, services and resources into 10 medical programs to meet the needs of our patients and help us make
the most of our resources.
At the heart of everything we do at UHN are our Healthcare Professionals. Refer a patient to one of our 12 medical programs. Learn more about the resources and opportunities available for professional growth.
University Health Network has grown to be one of the largest research and teaching hospital networks in Canada - pioneers in improving the lives of patients. Our long history of health professions education at Toronto General, Toronto Western, Princess Margaret and Toronto Rehab hospitals has consistently advanced the science of education.
University Health Network is a health care and medical research organization in
Toronto, Ontario, Canada. The scope of research and complexity of cases at UHN has made us a national and international
source for discovery, education and patient care.
Being touched by illness affects us in different ways. Many people want to give back to the community
and help others. At UHN, we welcome your contribution and offer different ways you can help so you can find one that suits you.
The Newsroom is the source for media looking for information about UHN or trying to connect with one
of our experts for an interview. It's also the place to find UHN media policies and catch up on our news stories, videos, media releases,
podcasts and more.
Researchers from UHN's Krembil Brain Institute have shed light on the long-term effects of deep brain stimulation on neuronal activity in a brain region involved in Parkinson's disease.
A hallmark feature of Parkinson's disease is an increase in a type of neuronal activity – known as beta oscillations – in the basal ganglia region of the brain. Previous studies suggest that deep brain stimulation applied to this region reduces motor symptoms of the disease by disrupting this form of patterned neuronal activity.
According to Krembil Senior Scientist
Dr. Robert Chen, however, beta oscillations are only one piece of the puzzle.
"When measuring the activity of large groups of neurons, the signals that we acquire are made up of oscillations, or patterned activity, as well as non–patterned, or aperiodic, activity, which is often viewed as background activity," says Dr. Chen, who is also a professor in the Division of Neurology in the Department of Medicine at the University of Toronto.
"To understand precisely how deep brain stimulation treats disease symptoms, we need to consider its long-term effects on patterned and non-patterned forms of neuronal activity."
To determine the long-term effects of deep brain stimulation in the basal ganglia, Dr. Chen's team recorded local neuronal activity in patients with Parkinson's disease during six study visits over 18 months. They then applied computational methods to separate the oscillatory and aperiodic components of the signals.
"It has previously been very challenging to study the long-term effects of deep brain stimulation on brain activity because we were limited to recording from neurons over a short period while surgically implanting the electrodes," explains Dr. Ghazaleh Darmani, a postdoctoral researcher in Dr. Chen's lab and the first author of the study.
"In this study, we were able to assess neural signals over a longer period because our patients had specialized devices that can record local activity throughout the study period."
The team discovered that deep brain stimulation increased aperiodic beta activity over time. In contrast, beta oscillations were stable over time.
These findings call into question the traditional view that deep brain stimulation treats Parkinson's disease symptoms by reducing beta oscillations in the basal ganglia, and highlight the need to consider different forms of neuronal activity when studying the disease and developing therapies.
The researchers also found that dopaminergic medications that are commonly used to treat the disease affect these two types of brain activity differently. These medications did not affect aperiodic beta activity but did suppress beta oscillations.
"Our findings suggest that beta oscillations and aperiodic activity represent distinct but complementary neural processes in Parkinson's disease," says Dr. Darmani. "Clarifying how each type of activity contributes to disease symptoms is an important step towards developing more targeted and effective deep brain stimulation treatments."
This work was supported by the Canadian Institutes of Health Research, Medtronic Inc. and UHN Foundation.