Our UHN programs and services are among the most advanced in the world. We have grouped our physicians, staff, services and resources into 10 medical programs to meet the needs of our patients and help us make the most of our resources.
University Health Network is a health care and medical research organization in Toronto, Ontario, Canada. The scope of research and complexity of cases at UHN has made us a national and international source for discovery, education and patient care.
Our 10 medical programs are spread across eight hospital sites – Princess Margaret, Toronto General, Toronto Rehab’s five sites, Toronto Western – as well as our education programs through the Michener Institute of Education at UHN. Learn more about the services, programs and amenities offered at each location.
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Find out how to get to and around our nine locations — floor plans, parking, public transit, accessibility services, and shuttle information.
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The Centre for Arthritis Diagnostic and Therapeutic Innovation bring cost-effective Next-Generation Sequencing solutions to the Krembil. We aim to foster collaboration and to help advance the research of Krembil Investigators working in the fields of arthritis, brain and vision.
The collaborative process begins by consulting with our Sequencing Specialist to plan, design and budget for the proposed sequencing project. Our Sequencing Specialist will work closely with lab personnel, providing guidance on sample preparation and training on library preparation; however, individual labs will be responsible for obtaining the reagents and making their sample libraries. Prior to sequencing, our Sequencing Specialist will assess the quality of the prepared libraries. After sequencing, the Centre’s Bioinformatician will process the data, and provide the Investigator with a counted list of miRNAs (or RNAs) for each sample for final analysis and interpretation.
For quotes and initial consultation, please contact
Dr. Starlee Lively.
As an emerging field in systems biology and a new branch in the field of "omics", metabolomics – which is the study of all the small molecules (<1500 Da) within a system – is gaining much interest in the scientific community, particularly in clinical research. Due to the close and near-instantaneous relationship of the metabolome with a biological state (healthy vs. disease), metabolites generally present as rapid indicators of perturbances within a dynamic biological system. As such, metabolomics can be used as a tool in clinical research for determining disease pathology, thereby helping to pave an alternative path towards improved engineering of treatments of various diseases.
At the Schroeder Arthritis Institute's Centre for Diagnostic and Therapeutic Innovation – Metabolomics Core Facility, liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS) is the platform of choice for conducting metabolomics studies. Our LC-HRMS equipment – a Thermo Scientific™ Vanquish™ Flex Binary UHPLC system utilized in combination with a Thermo Scientific™ Q Exactive™ Plus Hybrid Quadrupole-Orbitrap™ mass spectrometer (MS) – is dedicated to the evaluation and elucidation of metabolites from biological cells, tissues and fluids. This metabolomics platform provides high accuracy, precision and reproducibility via the high-throughput capabilities of the robust and reliable UHPLC system that can perform superior separation of metabolites originating from complex biological sources. In addition, the MS boasts technology for optimal precursor ion selection, molecular fragmentation, and is equipped with an Orbitrap™ mass analyzer with a resolution of up to 140 000, making it the ideal instrumentation for the identification and analysis of known and/or unknown small molecules.
To apply metabolomics to your research, whether hypothesis- (targeted) or non-hypothesis- (untargeted/discovery) driven, the steps of the metabolomics workflow are as outlined below. Since metabolomics studies start with the biological question, please email it to
Nikita Looby to get started!
A general price list that is associated with sample preparation and the use of the LC-HRMS system can be found below. A more accurate quote that is specific to your research needs can be generated by filling out the Request for Quotation.
This core facility is currently being developed under the supervision of Dr. Vinod Chandran.
Sample Preparation using SPME
LC- HRMS Analysis
Prices are valid from January 1, 2022 to December 1, 2022 and are subject to annual readjustment.
The Informatics core brings cost-effective integrative computational biology solutions to the Schroeder Arthritis Institute. We aim to foster collaboration and to help advance the research of Schroeder Investigators working across spectrum of arthritis conditions. The Informatics core is directed by Dr. Igor Jurisica
The collaborative process begins by consulting with the Computational Biologist to plan, design and budget for the analyses of interest. Our Computational Biologist will work closely with lab personnel to identify the analyses more appropriate to answer the research questions at hand and will be providing updates at specific checkpoints. After completion of the analyses, details about methods and resources used as well as results in table and publication-ready image format will be provided to the lab contact person.
For quotes and initial consultation, please contact our Computational Biologist,
Dr. Chiara Pastrello.
The Schroeder Arthritis Institute Biobank is one of the largest biobanks with over 500,000 high-quality samples. This biobank is comprised of biospecimens collected from our clinics, national and international collaborators and represents various forms of arthritis:
All biospecimens are located in a key-card access, remote temperature monitored location until further analysis is requested. The sample request undergoes ethical monitoring and governance to ensure compliance with all policies and guidelines from the Research Ethics Board and principal investigators are met.
If you are interested in more details about this biobank, please contact our biobank operations co-chairs Kim Perry and Julie Gagnier.
You will be contacted with information about your first appointment.
Please bring the following to your appointment. Not all of these items may be needed for your appointment. Our clinic or your referring doctor will let you know what you must bring.
Please arrive 15 minutes before your appointment.
When you arrive, you will sign in with the receptionist. You will need your health card (OHIP card) to sign-in. If you do not have an OHIP card, please bring another form of government-issued photo ID, such as a driver’s license or passport.
You may be given a Measuring Health Equity Questionnaire to fill out. This form contains questions about your background. We collect this information to find out who we serve and what unique needs you may have. The form is voluntary and you can choose ‘prefer not to answer’ to any or all questions. However, the information you choose to give us will help us improve the quality of care for you and others.
First appointments take longer than follow-up appointments. Your first appointment can take 2 hours or more. Follow-up appointments usually take 15 to 30 minutes. We do everything we can to stay on time but sometimes unforeseen circumstances may delay your appointment.
At the end of your first appointment, the nurse or doctor will give you a contact list for your health care team. If you don’t get a contact list, feel free to ask for it.
After every appointment, a member of your health care team will tell you about your next visit. Be sure you understand what is going to happen next. For example, know the time and place of your next visit or if someone will call you with this information.
If you are unsure about what your next steps are, don’t be afraid to ask a member of your team. We are here to help you.
We understand that reaching us by phone can sometimes be difficult. Often our phone lines are busy or are turned over to the message centre so our staff can prepare for clinic visits or help other patients. We make every effort to return your call within 24 hours. Our staff will try to reach you 2 times. If we are not able to reach you directly you may need to call us again.