Sent on behalf of Dr. Mohit Kapoor and Dr. Robert Inman,
Co-Directors of the Schroeder Arthritis Institute, UHN
ORTHOBIOLOGICS
The Schroeder Arthritis Institute has the great pleasure of announcing a new gift commitment of $6M from the Schroeder Foundation. This gift will enable the development and implementation of orthobiologics and cell therapies on a major scale. With this gift, the Schroeder Arthritis Institute has the opportunity to deliver a comprehensive, consolidated and coordinated pathway for developing, testing and implementing orthobiologics and cell therapies as a standard of care. The Schroeder Arthritis Institute will be the go-to center for established clinical protocols and patient outcomes to create a library of trusted data and published research.
Dr. Sowmya Viswanathan, Dr. Christian Veillette and Dr. Christopher Kim will move forward with the creation of this platform with an orthobiologics registry, research cohort study and a key clinical trial that will enable delivery of these advanced therapeutic products, benchmarking, and quality improvement. Congratulations to Dr. Veillette, Dr. Viswanathan, Dr. Kim and Anette Larsson, Senior Campaign Director for the Campaign to Cure Arthritis, for securing this philanthropic support.
5 YEAR IMPACT - PEER REVIEWED FUNDING AND PUBLICATIONS
We are pleased to share the last 5-year peer reviewed funding and publication record for the Schroeder Arthritis Institute. These numbers reflect an outstanding productivity of our scientists, clinician scientists, fellows and trainees within the four divisions (Hand, Orthopedics, Osteoporosis and Rheumatology) of the Schroeder Arthritis Institute. Congratulations to everyone at the Schroeder Arthritis Institute for their exceptional academic impact and productivity over the past 5 years.
NEW APPOINTMENTS AND PROMOTIONS
Associate Professor
Dr. Christian Veillette, Division Head of Orthopedics and Clinician Investigator as well as an Affiliate Scientist at Techna, has been promoted to Associate Professor at the Department of Surgery at the University of Toronto.
Consultant and Co-Editor
Dr. Herbert Von Schroeder, Schroeder Arthritis Institute Hand Surgeon and Clinician Investigator at the Krembil Research Institute, has been appointed as a Consultant for the Workplace Safety and Insurance Tribunal for a three-year term. He has been appointed as a Consultant at Mt. Sinai Hospital's Dovigi Clinic. Dr. Von Schroeder is also a co-editor on a recent book titled
"Biomimetics and Bionic Applications", Springer 2021.
Development Officer, Campaign to Cure Arthritis and Clinician Partner Program
Bob Hall is joining the Campaign to Cure Arthritis as a Development Officer. He will manage relationships with leadership level donors and focus on the identification of new prospective donors for the Schroeder Arthritis Institute pipeline. In his role, he will also work on increasing clinician engagement in the Campaign to Cure Arthritis and Clinician Partner Program.
Development Associate, Campaign to Cure Arthritis
April Kwak is joining the Campaign to Cure Arthritis as a Development Associate. April has extensive experience in roles requiring strong customer service, organizational skills and administrative support. She is joining the Foundation team with a strong background in the non-for-profit sector.
Scientific Counselor for the National Institute of Arthritis and Musculoskeletal and Skin Diseases
Dr. Robert Inman, Co-Director of the Schroeder Arthritis Institute and Senior Scientist at the Krembil Research Institute, has been appointed to the Board of Scientific Counselors (BSC) for the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS).
AWARDS, GRANTS AND RECOGNITIONS
Collaborative Pilot Grant Competition 2021
The Schroeder Arthritis Institute is pleased to announce the winners of the inaugural Collaborative Pilot Grant Competition.
Dr. Vinod Chandran and Dr. Sowmya Viswanathan secured funding for their project "Functional Characterization of the Innate Immune Cell Interactions in Osteoarthritis and Psoriatic Arthritis".
Dr. Joan Wither and Dr. Igor Jurisica secured funding for their project "An unbiased approach to identification of T cell functional differences between flaring and quiescent lupus patients.
The annual SPARCC Pilot Project Program competition has recently concluded with a total of 8 meritorious project proposals received in the area of Spondyloarthritis (SpA) research. Two out of three high ranking proposals were from the Schroeder Arthritis Institute.
Dr. Robert Inman, Dr. Igor Jurisica, Dr. Mohit Kapoor and Dr. Fataneh Tavasolian secured funding for their project titled "Epigenetic Modulation of Plasticity and Stability of T Cell Signatures in Ankylosing Spondylitis".
Dr. Akihiro Nakamura and Dr. Nigil Haroon secured funding for their project titled "Pre-Clinical Testing for therapeutic Potentials of in vivo Grade miR-148a-3p and miR-152-3p Mimics in Spondyloarthritis".
Dr. Robert Inman, Dr. Nigil Haroon and Dr. Vinod Chandran have secured funding from the University of Toronto - Immunology Department for their multicenter project titled "Speck COVID-19 Immunomodulator Vaccine Study".
Exceptional Practitioner Achievement Award
Leslie Soever, Physiotherapist Practitioner at the Schroeder Arthritis Institute, Division of Orthopaedics Surgery, was awarded the Exceptional Practitioner Achievement Award from the Department of Physiotherapy at the University of Toronto.
UHN/SHS Department of Medicine Citizenship Awards
Dr. Arthur Bookman in the Division of Rheumatology at the Schroeder Arthritis Institute, was selected as a winner for the UHN/SHS Department of Medicine Citizenship Awards for supporting educational activities in the Division of Rheumatology.
Arthritis Society Strategic Operating Grant and Lupus Canada Catalyst Grant
Dr. Zahi Touma, a Scientist at the Schroeder Arthritis Institute and the Krembil Research Institute and a Rheumatologist at the Toronto Western Hospital, has received the 2020 Arthritis Society Strategic Operating Grant (SOG) for his project titled "Modeling cognitive impairment in patients with systemic lupus erythematosus: Clinical phenotyping, predictive trajectory, and associated risk factors".
Dr. Touma was also awarded the Lupus Canada Catalyst Grant, for his project titled "A pilot study examining the relationship between cognitive dysfunction and cognitive fatigue in SLE using structural and functional MRIs of the brain and focusing on the underlying mechanisms".
New Frontiers in Research Fund
Dr. Heather Baltzer, Director of the Hand Program at the Schroeder Arthritis Institute and clinician investigator at Krembil Research Institute, was awarded the New Frontiers in Research Fund - Exploration grant for her project titled "Development of a smart thumb prosthetic: sensate capacity with low-cost design".
National Psoriasis Foundation Psoriatic Arthritis Grant and COVID-19 Immunity Task Force
Dr. Vinod Chandran, Associate Professor of Medicine at the University of Toronto and Scientist the Schroeder Arthritis Institute and Krembil Research Institute, was awarded renewal of the National Psoriasis Foundation Psoriatic Arthritis Diagnostic Test Grant, for his project "Multi-omic diagnostic test for psoriatic arthritis in psoriasis patients".
Dr. Chandran also secured funding through the COVID-19 Immunity Task Force for his multi-centre project titled "Safety immUnogenicity of Covid-19 vaCcines in systEmic immunE mediated inflammatory Diseases (SUCCEED)".
STUDENTSHIP AWARDS
Graduate Student, Clinical Fellowship and Research Fellowship Award Competition 2021
The Schroeder Arthritis Institute is pleased to announce the winners of the inaugural Graduate Student, Clinical Fellowship and Research Fellowship Award Competition.
Dr. Nupur Purohit, postdoctoral/clinical fellow supervised by Dr. Heather Baltzer and Dr. Igor Jurisica secured funding for her project titled "Identifying the molecular biomarkers and therapeutic targets of trapeziometacarpal osteoarthritis severity".
Dr. Fatemeh Alavi, postdoctoral/clinical fellow supervised by Dr. Angela Cheung and Dr. Raja Rampersaud, secured funding for her project titled "Spine surgery poor outcome reduction using preoperative measure".
Atoosa Ziyaeyan, MSc candidate supervised by Dr. Sowmya Viswanathan and Dr. Vinod Chandran secured funding for her project titled "Developing and characterizing an osteochondral model for psoriatic arthritis".
Krembil Research Day 2021
Brian Wu, a PhD candidate under the supervision of Dr. Mohit Kapoor at the Schroeder Arthritis Institute, won 1st prize in the Oral Presentation Graduate Student Category at Krembil Research Day 2021.
Lupus Foundation of America Gary S. Gilkeson Career Development Award
Dr. Carolina Munoz Grajales was awarded the Lupus Foundation of America Gary S. Gilkeson Career Development Award for a two-year fellowship to work under the supervision of Dr. Zahi Touma for her project titled “Elucidating the risk factors and trajectories for cognitive impairment in SLE".
Lupus Foundation of America Gina M. Finzi Memorial Student Summer Fellowship
Farnoosh Naderinabi, a Medical Student at Western University, was awarded the Lupus Foundation of America Gina M. Finzi Memorial Student Summer Fellowship to work under the supervision of Dr. Murray Urowitz on a project titled "Interferon Alfa as a biomarker to predict lupus nephritis response to treatment".
Canadian Rheumatology Association Research Studentship
Connor Maddock, a Medical Student at the University of Dublin, was awarded the Canadian Rheumatology Association Research Studentship to work under the supervision of Dr. Zahi Touma on a project titled "Factors associated with employment and disability in patients with SLE: A nested case-control study".
Lupus Foundation of America Gina M. Finzi Memorial Student Summer Fellowship
Seerat Chawla, a BSc Student at the University of California, Los Angeles, was awarded the Lupus Foundation of America Gina M. Finzi Memorial Student Summer Fellowship to work under the supervision of Dr. Zahi Touma on a project titled "Trajectories of depressive symptoms in systemic lupus erythematosus over time".
Canada Graduate Scholarship
John Koussiouris, a MSc candidate at the University of Toronto, was awarded the Canada Graduate Scholarship working under the supervision of Dr. Vinod Chandran.
National Psoriasis Foundation of America Summer Studentship Award
Sarah Geahchan, a BSc Student at the University of Toronto, was awarded the National Psoriasis Foundation of America Summer Studentship award to work under the supervision of Dr. Dafna Gladman on a project titled "Notch homolog 2 N-terminal-like (NOTCH2NL) is a possible biomarker of psoriatic arthritis susceptibility in patients with psoriasis".
Canadian Rheumatology Association Summer Studentship
Anika Spasov, a Medical Student at the University of Ottawa, was awarded the Canadian Rheumatology Association Summer Studentship to work under the supervision of Dr. Zahi Touma on a project titled "Sensitivity to Change Over Time of the Patient Reported Outcomes Measurement Information Systems (PROMIS) Computerized Adaptive Test (CAT) in Systemic Lupus Erythematosus (SLE)".
Canadian Association of Psoriasis Patients (CAPP) Studentship Award
Dhruv Sharma, a BSc Student at McMaster University, was awarded the Canadian Association of Psoriasis Patients (CAPP) studentship award to work under the supervision of Dr. Vinod Chandran on a project titled "Prognosis and Biomarker Studies in Psoriasis and Psoriatic Arthritis: Identification of fatty acid metabolites in serum of psoriatic arthritis patients using SPME-MS".
New Facility at the Schroeder Arthritis Institute
Facility Informatics Core
The Schroeder Arthritis Institute is pleased to launch the Informatics Core Facility. This facility brings cost-effective integrative computational biology solutions to the Schroeder Arthritis Institute. Its aim is to foster collaboration and to help advance the research of Institute Investigators working across spectrum of arthritis conditions. This facility is being directed by Dr. Igor Jurisica.
Click here to learn more.
NOTABLE LECTURES
Krembil Discovery Series Webinar: Schroeder Arthritis Institute: Decoding arthritis to find a cure
The UHN Foundation recently hosted a webinar series featuring the 3 institutes within Krembil. On June 15, 2021, the webinar featured the Schroeder Arthritis Institute and was joined by Dr. Donald Weaver, Director, Krembil Research Institute and Research Director, Krembil Brain Institute, UHN; Dr. Mohit Kapoor, Co-Director of Schroeder Arthritis Institute, Tony and Shari Fell Platinum Chair in Arthritis Research, and Senior Scientist, Krembil Research Institute, UHN; Dr. Zahi Touma, Scientist at the Schroeder Arthritis Institute and the Krembil Research Institute and a Rheumatologist at the Toronto Western Hospital; Dr. Timothy Leroux, Assistant Professor at the Department of Surgery at the University of Toronto and Orthopedic Surgeon at the Toronto Western Hospital; Dr. Sowmya Viswanathan, a Scientist at the Schroeder Arthritis Institute and the Krembil Research Institute and an Assistant Professor at the Institute of Biomedical Engineering at the University of Toronto, and moderator Christian Coté.
Click here for video.
ARTHRITIS IN THE NEWS
Career Journey of a Recent Schroeder Arthritis Institute Alumni
Dr. Anusha Ratneswaran, a former postdoctoral fellow at the Schroeder Arthritis Institute, was featured on the UHN Office of Research Trainees (ORT) website. The article featuring Dr. Ratneswaran's career journey was written by Kevin Robb, a PhD candidate under Dr. Viswanathan's supervision and an ORT Science Writer.
Click here to read the full article.
NOTABLE PUBLICATIONS
A Comparison of Patient and Surgeon Expectations of Spine Surgical Outcomes
Aoude A, Litowski M, Aldebeyan S, Fisher C, Hall H, Manson N, Bailey C, Ahn H, Abraham E, Nataraj A, Paquet J, Stratton A, Christie S, Cadotte D, Nicholls F, Soroceanu A, Rampersaud Y, Thomas K. Global Spine Journal. April 2021.
Click here for publication.
A meta-analysis of level I evidence comparing tenotomy vs tenodesis in the management of long head of biceps pathology
Zhu X, Leroux T, Ben-David E, Dennis B, Gohal C, Kirsch J, Khan M. Journal of Shoulder and Elbow Surgery. May 2021.
Click here for publication.
Arthroscopic Bankart Repair With Remplissage in Comparison to Bone Block Augmentation for Anterior Shoulder Instability With Bipolar Bone Loss: A Systematic Review
Gouveia K, Abidi S, Shamshoon S, Gohal C, Madden K, Degen R, Leroux T, Alolabi B, Khan M. Arthoscopy. May 2021.
Click here for publication.
Entrustable Professional Activities in Orthopaedics
Watson A, Leroux T, Ogilvie-Harris D, Nousiainen M, Ferguson P, Murnahan L, Dwyer T. JBJS Open Access. April 2021.
Click here for publication.
Factors Affecting Length of Stay Following 3-Column Spinal Osteotomies in Pediatric Patients
Kato S, Dear T, Lewis S. Global Spine Journal. March 2021.
Click here for publication.
Feasibility of achieving planned surgical margins in primary spine tumor: a PTRON study
Dandurand C, Fisher C, Rhines L, Boriani S, Charest-Morin R, Gasbarrini A, Luzzati A, Reynolds J, Wei F, Gokaslan Z, Bettegowda C, Sciubba D, Lazary A, Kawahara N, Clarke M, Rampersaud Y, Disch A, Chou D, Shin J, Hornicek F, Laufer I, Sahgal A, Dea N. Neurosurgical Focus. May 2021.
Click here for publication.
Fibroblast-like synoviocytes: Role in synovial fibrosis associated with osteoarthritis
Maglaviceanu A, Wu B, Kapoor M. Wound Repair and Regeneration. May 2021.
Click here for publication.
Identification of prosthetic hip and knee joint infections using administrative databases-A validation study
Kandel C, Jenkinson R, Widdifield J, Hansen B, Davey J, Muller M, Daneman N, McGeer A. European Spine Journal. March 2021.
Click here for publication.
Standards efforts and landscape for rapid microbial testing methodologies in regenerative medicine
Lin-Gibson S, Lin NJ, Jackson S, Viswanathan S, Zylberberg C, Wolfrum J, Basu S, Roy K, Marshall D, McFarland R, Hoover S, Rietze R, Getz A, Henke D. Cytotherapy. March 2021.
Click here for publication.
The inflammatory speech of fibroblasts
Schuster R, Rockel JS, Kapoor M, Hinz B. Immunological Reviews. May 2021.
Click here for publication.
Update on all-arthroscopic vs. mini-open rotator cuff repair: A systematic review and meta-analysis
Sakha S, Erdogan S, Shanmugaraj A, Betsch M, Leroux T, Khan M. Journal of Orthopaedics. March 2021.
Click here for publication.
Primary sarcomas of the spine: population-based demographic and survival data in 107 spinal sarcomas over a 23-year period in Ontario, Canada
Oitment C, Bozzo A, Martin A, Rienmuller A, Jentzsch T, Aoude A, Thornley P, Ghert M, Rampersaud R. The Spine Journal. March 2021.
Click here for publication.
What Goes Bump in the Night: An Evaluation of Emergency Department Visits Following Total Joint Arthroplasty
Maldonado-Rodriguez N, Gandhi R, Sundararajan K, Rampersaud Y, Nizar M, Leroux T. The Journal of Arthroplasty. April 2021.
Click here for publication.
International comparative study of low back pain care pathways and analysis of key interventions
Coeckelberghs E, Verbeke H, Desomer A, Jonckheer P, Fourney D, Willems P, Coppes M, Rampersaud R, van Hooff M, van den Eede E, Kulik G, de Goumoëns P, Vanhaecht K, Depreitere B. European Spine Journal. April 2021.
Click here for publication.
Interpretation use for consent to hip fracture surgery in patients with limited English proficiency
Mong J, Cram P, Syed K, Rawal S. Journal of the American Geriatrics Society (JAGS). April 2021.
Click here for publication.
Implementation of the Good Life with OsteoArthritis in Denmark (GLA:D) Program across Canada for the Management of Hip and Knee Osteoarthritis
Zywiel M, Ellis K, Veillette C, Skou S, McGlasson R. Healthcare Quarterly (Toronto Ont). April 2021.
Click here for publication.
Recognition of posterior thoracolumbar instrumentations used in spinal deformity surgery and techniques for implant removal
Kato S, Lewis S. Journal of Clinical Neuroscience. April 2021.
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Hyaluronate Carboxymethylcellulose Sheets for the Prevention of Adhesive Complications: A Model-Based Cost-Utility Analysis
Sue-Chue-Lam C, Zhang D, Baxter N, Zywiel M, de Mestral C. Colorectal Disease. May 2021.
Click here for publication.
CORR Insights: Are Narrative Letters of Recommendation for Medical Students Interpreted as Intended by Orthopaedic Surgery Residency Programs?
Zywiel, M. Clinical Orthopaedics and Related Research. April 2021.
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Lumbar degenerative spondylolisthesis: factors associated with the decision to fuse
Schneider N, Fisher C, Glennie A, Urquhart J, Street J, Dvorak M, Paquette S, Charest-Morin R, Ailon T, Manson N, Thomas K, Rasoulinejad P, Rampersaud R, Bailey C. The Spine Journal. May 2021.
Click here for publication.
The impact of pathoanatomical diagnosis on elective spine surgery patient expectations: a Canadian Spine Outcomes and Research Network study
Glennie R, Canizares M, Perruccio A, Abraham E, Nicholls F, Nataraj A, Phan P, Attabib N, Johnson M, Richardson E, McIntosh G, Ahn H, Fisher C, Manson N, Thomas K, Rampersaud Y. Journal of Neurosurgery. May 2021.
Click here for publication.
Psychological interventions to reduce postoperative pain and opioid consumption: a narrative review of literature
Gorsky K, Black N, Niazi A, Saripella A, Englesakis M, Leroux T, Chung F, Niazi A. Regional Anesthesia and Pain Medicine. May 2021.
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Prevention and Treatment of Nerve Injuries in Shoulder Arthroplasty
Florczynski M, Paul R, Leroux T, Baltzer H. Journal of Bone Joint Surgery. American Volume. May 2021.
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Stemless reverse total shoulder arthroplasty: a systematic review of short-and mid-term results
Liu E, Kord D, Yee N, Horner N, Al Mana L, Leroux T, Alolabi B, Khan M. Shoulder & Elbow. May 2021.
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Paradoxical role of IL6 signalling in osteoarthritis
Rabani R, Rasti M, Chan M, Mahomed N, Gandhi R, Viswanathan S. Cytotherapy. May 2021.
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Pro-resolving macrophages as a cell-based therapy in osteoarthritis by adoptive transfer within murine in vivo and human explant ex vivo investigation
Chan M, Ziyaeyan A, Rasti M , Gabrial S, Kapoor M, Mahomed N, Gandhi R, Viswanathan S. Cytotherapy. May 2021.
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Microrna signature of mesenchymal stromal cells contributes to their therapeutic efficacy in the context of osteoarthritis
Rabani R, Robb K.P, Chahal J, Mahomed N, Gandhi R, Viswanathan S. Cytotherapy. May 2021.
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Factors predictive of radiographic progression in ankylosing spondylitis
Sari I, Lee S, Tomlinson G, Johnson SR, Inman RD, Haroon N. Arthritis Care & Research. February 2021.
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Tumor necrosis factor inhibitor dose reduction for axial spondyloarthritis: A systematic review and meta-analysis of randomized controlled trials
Lawson DO, Eraso M, Mbuagbaw L, Joanes M, Aves T, Leenus A, Omar A, Inman RD. Arthritis Care & Research. June 2021.
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Abnormal subgenual anterior cingulate circuitry is unique to women but not men with chronic pain
Osborne NR, Cheng JC, Rogachov A, Kim JA, Hemington KS, Bosma RL, Inman RD, Davis KD. Pain. January 2021.
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Sex-differences in brain modular organization in chronic pain
Fauchon C, Meunier D, Rogachov A, Hemington K, Cheng J, Bosma R, Osborne N, Kim JA, Hung P, Inman RD, Davis KD. Pain. April 2021.
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Pain in axial spondyloarthritis: Insights from immunology and brain imaging
Pathan E, Inman RD. Rheumatic Disease Clinics of North America. May 2021.
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The gut-joint axis in spondyloarthritis: immunological, microbial and clinical insights
Qaiyum Z, Lim M, Inman RD. Seminars in Immunopathology. April 2021.
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Axial Spondyloarthritis: Current Advances, Future Challenges
Inman RD. Journal of Rheumatic Diseases. April 2021.
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Serum metabolic fingerprinting of psoriasis and psoriatic arthritis patients using solid-phase microextraction-liquid chromatography-high-resolution mass spectrometry
Looby N, Roszkowska A, Reyes-Garcés N, Yu M, Bączek T, Kulasingam V, Pawliszyn J, Chandran V. Metabolomics. June 2021.
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Assessment of cardiovascular risk tools as predictors of cardiovascular disease events in systemic lupus erythematosus
Sivakumaran J, Harvey P, Omar A, Tayer-Shifman O, Urowitz MB, Gladman DD, Anderson N, Su J, Touma Z. Lupus Science & Medicine. May 2021.
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Metrics and definitions used in the assessment of cognitive impairment in systemic lupus erythematosus: A systematic review
Qaiyum Z, Lim M, Inman RD.Yuen K, Green R, Bingham K, Ruttan L, Lee-Kim V, Tartaglia MC, Anderson M, Zandy M, Choi MY, Fritzler MJ, Wither JE, Beaton DE, Katz P, Touma Z. Seminars in Arthritis and Rheumatism. June 2021.
Click here for publication.
