ALERT CONTENT PLACEHOLDER

Sent on behalf of Dr. Mohit Kapoor and Dr. Robert Inman, Co-Directors of the Schroeder Arthritis Institute, UHN

Arthritis Program Newsletter

Happy Holidays

SPECIAL FEATURE

 

The special features included in each newsletter highlight some of the outstanding individuals who have contributed immensely towards the success of each division of the Schroeder Arthritis Institute. Our inaugural feature highlighted Silvi Groe in the fall edition of the newsletter. If you have missed this feature, please follow this link.

In this edition, we are highlighting an outstanding individual who has made a huge impact towards the growth and success of the Division of Orthopedic's Osteoarthritis Research Program at the Schroeder Arthritis Institute.

Dr. Glenys Foster Roberts, Director of Research Operations, Osteoarthritis Research Program

Dr. Glenys Foster Roberts  

Dr. Glenys Foster Roberts is the Director of Research Operations within the Division of Orthopedic's Osteoarthritis Research Program at the Schroeder Arthritis Institute. Before joining the Osteoarthritis Research Program back in 2012, Glenys had spent over 20 years in the pharmaceutical industry and was looking for a way to use her knowledge to give back.

She heard about the orthopedic surgeons at Toronto Western Hospital through the Buchan Family Foundation. The Osteoarthritis Research Program that Dr. Nizar Mohamed and Dr. Wayne Marshall were developing, in order to find a cure for osteoarthritis, sparked an interest for Glenys, which ultimately encouraged her to join the team as a volunteer. What was fascinating to Glenys is that Dr. Mohammed and Dr. Marshall started the fund-raising activities for the collaborative research program with substantial financial contributions from each of the 10 surgeons in the Division, prior to approaching philanthropists for support. Their approach expressed their commitment and dedication to the program to other potential donors.

Glenys generously came in as a volunteer with a vision to help create a cohesive team of researchers who would work both independently and together to achieve the program's goal.

One thing that stood out to her was how patient-centric the research was. With previous experience in managing large research groups, operational staff in laboratories, and research facilities, Glenys was able to develop a cross-functional team that helped each other achieve their desired goals. Another key role that Glenys proudly took on was setting up the required infrastructure. This allowed for staff members to see a career path and have the opportunity to grow in their field within the Osteoarthritis Research Program. A crucial change she oversaw was developing financial systems so that the Division of Orthopedics and its Osteoarthritis Research Program could show financial accountability to the donors. Glenys worked closely with Anette Larsson, the Director of the Campaign to Cure Arthritis, and the surgeons to ensure that annual reports convey meaningful information to the donors. In addition, she brought in a research manager to help administer day-to-day operations and inspire the team. Glenys has definitely shown exceptional work and leadership that has contributed to the growth and development of the OA Research Program.

Since Glenys started as a volunteer and did not have access to all of the information she needed to make the changes that she envisioned, Glenys was asked to become an employee. This is when she was appointed as the Director of Research Operations. Since then, she has participated in a number of large projects such as LEAP OA, using a data capture system DADOS, and organized the first Academic Advisory Board meeting. She was also present when the wet lab scientific program was established in the Buchan Arthritis Research Center in the Krembil Discovery Tower.

All the positive changes that Glenys made were in hopes of achieving the ability to translate scientific knowledge from the research team to the patient. Helping the patient benefit from any research that was being done was and still is one of her most important goals. Glenys points out that "It's always been so patient-centric", and she has truly been inspired by all of the work the surgeons and researchers have done.

The biggest motivation for Glenys is the chance to make a positive difference, especially for the patients. She finds great joy in helping the organization and having put in the infrastructure that she has. "That was the motivation. To see what the vision was, to buy into that vision, and to actually be able to make it happen."

When asked what her Mantra of Success is, she expressed that it's to have open communication. She stressed that success comes from the process of encouraging people to strive for excellence. Motivating others to "continue to grow and improve within themselves" is what success really is.

Accomplishing the vision that the orthopedic surgeons initially had is an enormous achievement. After years of research, it's truly incredible that better treatments are being offered to the patients. Glenys would like to express her great appreciation for all the surgeons, Dr. Kapoor and the scientists for their contributions to the research and leadership throughout the years.

It has been an exciting 10 years for Glenys, having the opportunity to work with such a collaborative and sustainable team.

In her personal life, Glenys loves to travel the world and visit as many countries as she can. A little secret she shared is that she uses her passion for bird watching as an excuse, or a stepping-off point, to travelling the world.

On behalf of the Schroeder Arthritis Institute and its Division of Orthopedic's, we are thankful to Glenys's exceptional contribution towards the growth and success of the Osteoarthritis Research Program.

NEW APPOINTMENTS AND PROMOTIONS

 

Clinical Manager of the Schroeder Arthritis Institute Outpatient Clinics

Lisa Giraldi, Clinical Manager of 9A Orthopedics, was recently appointed to the role of permanent full-time Clinical Manager of the Schroeder Arthritis Institute Outpatient Clinics.

Lisa Giraldi  
 

Dr. Raja Rampersaud  

Celebration Event, Appointment of the J. Bernard Gosevitz Chair in Arthritis Research

The appointment of Dr. Raja Rampersaud as the inaugural J. Bernard Gosevitz Chair in Arthritis Research took place virtually where Dr. Rampersaud presented his vision. Dr. Rampersaud is an Orthopedic Surgeon and the Director of the Osteoarthritis Research Program within the Division of Orthopedics at the Schroeder Arthritis Institute, and a clinical investigator at the Krembil Research Institute. The celebration for his appointment took place on Wednesday, November 3rd, 2021. Click here for the Celebration Video

 

Clinical Manager of the Schroeder Arthritis Institute Inpatient Unit

Indira Gobin was recently appointed to the role of permanent full-time Clinical Manager of the Schroeder Arthritis Institute Inpatient Unit at Toronto Western Hospital.

Indira Gobin  
 

Promotion to Senior Scientist

Dr. Anthony Perruccio  

Dr. Anthony Perruccio has been promoted from Scientist to Senior Scientist at the Schroeder Arthritis Institute, Krembil Research Institute.


Dr. Armand Keating  

Dr. Armand Keating has been promoted from Scientist to Senior Scientist at the Schroeder Arthritis Institute, Krembil Research Institute.


Dr. Nigil Haroon  

Dr. Nigil Haroon has been promoted from Scientist to Senior Scientist at the Schroeder Arthritis Institute, Krembil Research Institute.

 

Osteoarthritis Research Society International (OARSI) Board of Directors

Dr. Mohit Kapoor, was recently appointed on the Board of Directors for the Osteoarthritis Research Society International (OARSI). His tenure on the board will commence in 2022.

Dr. Mohit Kapoor  

AWARDS, GRANTS AND RECOGNITIONS

 

The Arthritis Society (TAS) - Ignite Innovation Grant

Dr. Vinod Chandran  

Dr. Vinod Chandran, co-director of the Psoriatic Arthritis Research Program and scientist at the Schroeder Arthritis Institute and Krembil Research Institute, secured funding for his project titled "Improving outcomes by understanding flares in psoriatic arthritis: Patient-centric approach with in-home monitoring of symptoms, biomarkers and physical activity" through The Arthritis Society (TAS) - Ignite Innovation Grant 2021.


Dr. Armand Keating  

Dr. Armand Keating, scientist at the Schroeder Arthritis Institute and Krembil Research Institute, secured funding for his project titled "Bone marrow lesions in osteoarthritis: Genomics and core pathophysiology" through The Arthritis Society (TAS) - Ignite Innovation Grant 2021.

 
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Canadian Institute of Health Research Awards $2M to study the link between diabetes and OA

CIHR logo  

CIHR as part of the Diabetes Mechanisms and Translational Solutions awarded team grant spearheaded by Principle Investigators, Dr. Minna Woo, Dr. Mohit Kapoor, Dr. Angela Cheung, Dr. Gilles Gouspillou and Dr. Matthew Grol, as well as a team of co-investigators (Dr. Igor Jurisica, Dr. Jason Rockel, Dr. Shirine Usmani and others) for their team project titled "To investigate the Central role of muscle autophagy in metabolism and musculoskeletal health", through the CIHR Team Grant, Diabetes Mechanisms and Translational Solutions.

 

Dr. Patricia Remalante-Rayco  

The Asia Pacific League of Associations for Rheumatology (APLAR) Fellowship Grant

Dr. Patricia Remalante-Rayco, Clinical Fellow at the Department of Rheumatology, secured funding for her project titled "A Prospective, Randomized Biologic Tapering Study of TNF Inhibitors in Axial Spondyloarthritis (BIOTAPE Study)", through the APLAR Fellowship Grant.

 

PODCASTS

 

Behind the Breakthrough Podcast

 

Check out this episode of Behind the Breakthrough podcast. Dr. Joan Wither, senior scientist at the Schroeder Arthritis Institute and the Krembil Research Institute, discusses searching for the genetic and immune system abnormalities that lead to systemic autoimmune rheumatic diseases.


Check out this episode of Behind the Breakthrough podcast. Dr. Angela Cheung, Director of the Osteoporosis Program at the Schroeder Arthritis Institute, discusses her research on over 100 symptoms for Covid patients along with treatment options.

 
 

RETIREMENT

 

Happy Retirement

After many years working with the University Health Network, MaryAnn Dow, Manager of the Schroeder Arthritis Institute Outpatient Clinics, is announcing her well-deserved retirement. On behalf of the Schroeder Arthritis Institute, we are thankful for her outstanding contribution throughout the years and wish her all the best in the future.

MaryAnn Dow  
 

ARTHRITIS IN THE NEWS

 

 

Innovation in 3D Imaging

Dr. Timothy Leroux, Clinical Investigator at the Schroeder Arthritis Institute and Krembil Research Institute, and Orthopaedic Surgeon, is leading innovation in 3D imaging and mixed reality tools, working alongside colleagues at the Joint Department of Medical Imaging at the UHN, in hopes to transform positioning and overall outcomes for shoulder replacement patients. Click here for more information.

 

Best Health Magazine Women of The Year

Dr. Angela Cheung, Director of the Osteoporosis Program at the Schroeder Arthritis Institute, was recently included as one of the Women of The Year for Best Health Magazine. She was recognized for her longitudinal study, CANCOV, looking at short and long term outcomes of Covid-19. Click here for more information

Dr. Angela Cheung  
 

Spondyloarthritis Research Consortium of Canada (SPARCC) Meeting

Dr. Dafna Gladman and Dr. Robert Inman, senior scientists at the Schroeder Arthritis Institute and Krembil Research Institute, virtually spearheaded SPARCC's annual scientific meeting. SPARCC's investigators, collaborators, and stakeholders attended the meeting on October 22, 2021.

 

Science Translational Medicine Journal Publication

Dr. Nigil Haroon, scientist at the Schroeder Arthritis Institute and Krembil Research Institute and Dr. Akihiro Nakamura, Clinical Fellow and PhD candidate in Dr. Haroon's lab, recently had their new research study titled "Macrophage migration inhibitory factor drives pathology in a mouse model of spondyloarthritis and is associated with human disease" published in the Science Translational Medicine journal. Click here for more information.

 

Osteoarthritis Symposium: Academic Advisory Meeting 2021

The Schroeder Arthritis Institute's Division of Orthopedic's Osteoarthritis Research Program hosted a virtual Symposium as part of the biennial Academic Advisory Board (AAB) meeting which took place on Thursday, November 11, 2021. This symposium titled "OA Patients and OA Advocacy The Heart of the Matter" was co-chaired by Dr. Timothy Leroux and Dr. Anthony Perruccio and was attended by the Academic Advisory Board members, patient partners, general public, clinicians, scientists, trainees and staff.

 

NOW Magazine Feature

From left in the above image: Dr. Rod Davey (orthopedic surgeon and clinician-scientist at the Schroeder Arthritis Institute and Krembil Research Institute), Amanda Ma (registered nurse), Dr. Rajiv Gandhi (orthopedic surgeon and clinician-scientist at the Schroeder Arthritis Institute and Krembil Research Institute), Kendra Willis (registered nurse and patient coordinator), Dr. Michael Zywiel (orthopedic surgeon and clinician-scientist at the Schroeder Arthritis Institute and Krembil Research Institute) were recently featured in NOW magazine on how same day hip replacement surgeries lead to quicker patient recoveries. Click here for more information

 
 

UPCOMING CONFERENCE

 

The Schroeder Arthritis Institute will be organizing an International Conference on Arthritis, integrating clinical care, education, and research in arthritis, on October 13th and 14th in 2022. Please save the date for this exciting event in 2022.

Shroewder Arthritis Institute presents International Conference on Arthritis: Convergence of Care, Education & Research. Save the date October 13 & 14, 2022  
 

NOTABLE PUBLICATIONS

 

A Network Biology Approach to Understanding the Tissue-Specific Roles of Non-Coding RNAs in Arthritis.

Ali SA, Pastrello C, Kaur N, Peffers MJ, Ormseth MJ, Jurisica I. Front Endocrinol (Lausanne). Nov 2021.
Click here for publication

 

Assessment of the Toronto Psoriatic Arthritis Screen 2 as a Screening Tool for Psoriasis.

Taylor JH, Deo M, Sutton M, Chandran V, Shanmugarajah S, Pereira D, Gladman DD, Rosen CF. J Cutan Med Surg. Nov 2021.
Click here for publication

 

Basal insulin plus GLP-1 RA or SGLT2 inhibitor was noninferior to basal-bolus insulin intensification for HbA1c in T2DM.

Boggild MK, Cheung AM.Ann Intern Med. Sep 2021.
Click here for publication

 

Consensus International Council for Commonality in Blood Banking Automation-International Society for Cell & Gene Therapy statement on standard nomenclature abbreviations for the tissue of origin of mesenchymal stromal cells

Viswanathan S, Ciccocioppo R, Galipeau J, Krampera M, Le Blanc K, Martin I, Moniz K, Nolta J, Phinney DG, Shi Y, Szczepiorkowski ZM, Tarte K, Weiss DJ, Ashford P. Cytotherapy. Dec 2021.
Click here for publication

 

Differentiation of pain related functional limitations in surgical patients with Lumbar Spinal Stenosis (LSS) using the ODI: a Canadian Spine Outcomes and Research Network (CSORN) study

Charalampidis A, Canizares M, Kalsi PS, Hung Wu P, Johnson M, Soroceanu A, Nataraj A, Glennie A, Rasoulinejad P, Attabib N, Hall H, Fisher C, Thomas K, Raja Rampersaud Y. Spine J. Oct 2021.
Click here for publication

 

IgG4-related disease in a patient with ankylosing spondylitis: Clues to common immunopathogenesis

Wojcik S, Inman RD. Nakamura A. J Rheumatol. Sept 2021.
Click here for publication

 

IID 2021: towards context-specific protein interaction analyses by increased coverage, enhanced annotation and enrichment analysis

Kotlyar M, Pastrello C, Ahmed Z, Chee J, Varyova Z, Jurisica I. Nucleic Acids Res. Nov 2021.
Click here for publication

 

Improving Analysis and Annotation of Microarray Data with Protein Interactions

Kotlyar M, Wong SWH, Pastrello C, Jurisica I. Methods Mol Biol. Jan 2022.
Click here for publication

 

Longitudinal relationships between cognitive domains and DEPRESSION and anxiety symptoms in systemic lupus erythematosus

Bingham KS, DiazMartinez J, Green R, Tartaglia MC, Ruttan L, Su J, Wither JE, Kakvan M, Anderson N, Bonilla D, Choi MY, Fritzler MJ, Beaton DE, Katz P, Touma Z. Semin Arthritis Rheum. Sep 2021.
Click here for publication

 

Macrophage migration inhibitory factor drives pathology in a mouse model of spondyloarthritis and is associated with human disease

Nakamura A, Zeng F, Nakamura S, Reid KT, Gracey E, Lim M, Leng L, Jo S, Park YS, Kusuda M, Machhar R, Boroojeni SF, Wu B, Rossomacha E, Kim TH, Ciccia F, Rockel JS, Kapoor M, Inman RD, Jurisica I, Crome SQ, Bucala R, Haroon N. Sci Transl Med. Oct 2021.
Click here for publication

 

miRAnno-network-based functional microRNA annotation

Tokar T, Pastrello C, Abovsky M, Rahmati S, Jurisica I. Bioinformatics. July 2021.
Click here for publication

 

Motivators, barriers, and opportunity for e-health to encourage physical activity in axial spondyloarthritis: a qualitative descriptive study

Passalent L, Cyr A, Jurisica I, Mathur S, Inman RD, Haroon N. Arthritis Care Res. Oct 2021.
Click here for publication

 

Pathway Enrichment Analysis of Microarray Data

Pastrello C, Niu Y, Jurisica I. Methods Mol Biol. 2022.
Click here for publication

 

Proceedings of the 2021 Santa Fe Bone Symposium: Advances in the Management of Osteoporosis and Metabolic Bone Diseases

Lewiecki EM, Anderson PA, Bilezikian JP, Binkley N, Cheung AM, Imel EA, Krueger D, McClung MR, Miller PD, Rothman MS.J Clin Densitom. Oct 2021.
Click here for publication

 

Revision surgery following minimally invasive decompression for lumbar spinal stenosis with and without stable degenerative spondylolisthesis: a 5- to 15- year reoperation survival analysis

Moayeri N, Rampersaud YR.. J Neurosurg Spine. Oct 2021.
Click here for publication

 

Serial Lipocalin 2 and Oncostatin M levels reflect inflammation status and treatment response in axial spondyloarthritis

Tsui FWL, Lin A, Sari I, Zhang Z, Tsui HW, Inman RD. Arth Res Ther. May 2021.
Click here for publication

 

The future of deep phenotyping in osteoarthritis: How can high throughout omics technologies advance our understanding of the cellular and molecular taxonomy of the disease?

Mobasheri A, Kapoor M, Ali SA, Lang AM, Madry H. Osteoarthritis and Cartilage Open. Dec 2021.
Click here for publication

 

The MoveStrong program for promoting balance and functional strength training and adequate protein intake in pre-frail older adults: A pilot randomized controlled trial

Rodrigues IB, Wang E, Keller H, Thabane L, Ashe MC, Brien S, Cheung AM, Funnell L, Jain R, Loong D, Isaranuwatchai W, Milligan J, Mourtzakis M, Papaioannou A, Straus S, Weston ZJ, Giangregorio LM. PLoS One. Sep 2021.
Click here for publication

 

Tumour necrosis factor inhibitor dose reduction for axial spondyloarthritis: A systemic review and meta-analysis of randomized controlled trials

Lawson DO, Eraso M, Mbuagbaw L, Joanes M, Aves T, Leenus A, Omar A, Inman RD. Arthritis Care. June 2021.
Click here for publication

 

Understanding the Association Between Osteoarthritis and Social Participation: The Canadian Longitudinal Study on Aging

Perruccio AV, Yip C, Power JD, Canizares M, Gignac MAM, Badley EM. Arthritis Care Res (Hoboken). Nov 2021.
Click here for publication

 

Validity and reliability of patient reported outcomes measurement information system computerized adaptive tests in systemic lupus erythematous

Moazzami M, Katz P, Bonilla D, Engel L, Su J, Akhavan P, Anderson N, Tayer-Shifman OE, Beaton D, Touma Z. Lupus. Nov 2021.
Click here for publication