Our UHN programs and services are among the most advanced in the world. We have grouped our physicians, staff, services and resources into 10 medical programs to meet the needs of our patients and help us make the most of our resources.
University Health Network is a health care and medical research organization in Toronto, Ontario, Canada. The scope of research and complexity of cases at UHN has made us a national and international source for discovery, education and patient care.
Our 10 medical programs are spread across eight hospital sites – Princess Margaret, Toronto General, Toronto Rehab’s five sites, Toronto Western – as well as our education programs through the Michener Institute of Education at UHN. Learn more about the services, programs and amenities offered at each location.
Maps & Directions
Find out how to get to and around our nine locations — floor plans, parking, public transit, accessibility services, and shuttle information.
Ways You Can Help
Being touched by illness affects us in different ways. Many people want to give back to the community and help others. At UHN, we welcome your contribution and offer different ways you can help so you can find one that suits you.
The Newsroom is the source for media looking for information about UHN or trying to connect with one of our experts for an interview. It’s also the place to find UHN media policies and catch up on our news stories, videos, media releases, podcasts and more.
Clinical researchers at the Peter Munk Cardiac Centre (PMCC) have discovered a gene that may help unravel the mystery surrounding the most common form of heart rhythm disorder – atrial fibrillation – specifically when inherited by family members.
"Atrial fibrillation is very common," says Dr. Michael Gollob, cardiologist and clinical electrophysiologist at PMCC, who led the study. "It is a very challenging arrhythmia to control, both with medical therapy and cardiac procedures.
"Many patients become refractory to medical therapy or become intolerable to side-effects."
The study, entitled "A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation," appears in the April 2016 edition of
The study focused on examining the genes of five members of the same family, all of whom are from Canada and each of whom had atrial fibrillation, a chronic condition.
"We analyzed their genes using cutting-edge genomic technology," says Dr. Gollob, who was recruited by PMCC in 2014 and is a leading international expert on the electrical malfunctions of the heart and abnormal heartbeats. "We performed whole exome sequencing on the DNA of affected individuals and compared that to other members of the family who did not have the disease and looked at the DNA profiles of both the affected and unaffected individuals."
Dr. Gollob is also the Chair of the Peter Munk Centre of Excellence in Molecular Medicine.
"Using this type of genetic study, we were able to identify some rare genetic variants that affected members in the family carried, that unaffected members did not carry," Dr. Gollob says. "One of these genetic findings was a novel genetic mutation in a gene that is highly expressed it he atrial chambers of the heart.
"And this particular gene encodes a protein that is involved in the structure of the atrial myocardium. And this was a novel mutation that all affected members of the family had."
"This type of study is what drives us to perform gene discovery research," Dr. Gollob says. "These findings together with the genetic observations were rather conclusive in suggesting that we had identified a novel gene, in a Canadian family, responsible for atrial fibrillation."