At UHN, we strive to deliver Compassionate Care & Caring. Learn more about the services and supports that are available to you throughout your journey.
Our UHN programs and services are among the most advanced in the world. We have grouped our physicians,
staff, services and resources into 10 medical programs to meet the needs of our patients and help us make
the most of our resources.
At the heart of everything we do at UHN are our Healthcare Professionals. Refer a patient to one of our 12 medical programs. Learn more about the resources and opportunities available for professional growth.
University Health Network has grown to be one of the largest research and teaching hospital networks in Canada - pioneers in improving the lives of patients. Our long history of health professions education at Toronto General, Toronto Western, Princess Margaret and Toronto Rehab hospitals has consistently advanced the science of education.
University Health Network is a health care and medical research organization in
Toronto, Ontario, Canada. The scope of research and complexity of cases at UHN has made us a national and international
source for discovery, education and patient care.
Being touched by illness affects us in different ways. Many people want to give back to the community
and help others. At UHN, we welcome your contribution and offer different ways you can help so you can find one that suits you.
The Newsroom is the source for media looking for information about UHN or trying to connect with one
of our experts for an interview. It's also the place to find UHN media policies and catch up on our news stories, videos, media releases,
podcasts and more.
Crowdsourcing is a concept in which large groups of people work together to fulfill a common goal. The idea is that there is strength in numbers: as more people make individual contributions, the work that needs to be done is finished quicker.
In his own way, Krembil Senior Scientist Dr. Igor Jurisica has been applying a similar concept—called integrative computational biology—throughout his career.
He is a pioneer in using this technique to create large-scale tools for the research community that integrate data from his own research and those of his peers. These tools offer pooled data to an unprecedented breadth and diversity that could not be created by one team alone.
Dr. Jurisica's latest release is an updated version of mirDIP, the microRNA Data Integration Portal that his group introduced in 2011. It uses sophisticated computational approaches to predict which genes are controlled by microRNAs, short RNA molecules that regulate the activity of specific target genes.
Given this important function, the role of microRNAs in gene-related diseases, such as cancer and arthritis, are of great interest to the research community. Identifying which microRNAs modify which target genes would inform the development of new therapies to enhance—or block—these interactions.
To develop the mirDIP update, Dr. Jurisica and his research team summarized the data from 30 different microRNA prediction algorithms and databases.
After applying complex mathematical approaches to account for the different methodologies used by each of the databases, the team finalized a set of more than 151 million predictions—approximately 75 per cent more predictions than the next largest microRNA prediction database—in this release focusing on human systems. The team also developed an algorithm that assigns a score to each prediction.
"This score provides users with a measure of the confidence of each prediction," explains Dr. Jurisica. "Researchers can now access these predictions in one place—accelerating the research pipeline towards creating new therapies for diseases."
This work was supported by the Krembil Foundation; the Ministry of Research, Innovation and Science; the Canadian Cancer Society Research Institute; the Natural Sciences and Engineering Research Council of Canada; the Canada Foundation for Innovation; the Canada Research Chairs Program; and IBM.