Our UHN programs and services are among the most advanced in the world. We have grouped our physicians, staff, services and resources into 10 medical programs to meet the needs of our patients and help us make the most of our resources.
University Health Network is a health care and medical research organization in Toronto, Ontario, Canada. The scope of research and complexity of cases at UHN has made us a national and international source for discovery, education and patient care.
Our 10 medical programs are spread across eight hospital sites – Princess Margaret, Toronto General, Toronto Rehab’s five sites, Toronto Western – as well as our education programs through the Michener Institute of Education at UHN. Learn more about the services, programs and amenities offered at each location.
Maps & Directions
Find out how to get to and around our nine locations — floor plans, parking, public transit, accessibility services, and shuttle information.
Ways You Can Help
Being touched by illness affects us in different ways. Many people want to give back to the community and help others. At UHN, we welcome your contribution and offer different ways you can help so you can find one that suits you.
The Newsroom is the source for media looking for information about UHN or trying to connect with one of our experts for an interview. It’s also the place to find UHN media policies and catch up on our news stories, videos, media releases, podcasts and more.
Imagine superheroes who can destroy their enemies by engulfing them whole, acquire new powers to ward off unfamiliar threats and enlist the help of others when the going gets tough.
To find such superheroes, you'd have to look no further than your own body. Monocytes – the largest cells circulating in the blood – have all of these capabilities and more. They patrol the blood for disease-causing bacteria and viruses and use their "special powers" to eliminate them.
Dr. Nigil Haroon, a Scientist at Krembil Research Institute, has recently shown that instead of fighting disease, some monocytes contribute to it. He and his team have
found evidence suggesting that some monocytes worsen the symptoms of ankylosing spondylitis (AS) – a form of spinal arthritis.
AS is characterized by inflammation, stiffness of the spine and chronic back pain. Unusually, over half of those with the condition also have gut inflammation. Researchers have been trying to understand the mechanisms behind this puzzling connection.
By analyzing spinal tissues of AS patients who have gut inflammation, Dr. Haroon's team made a startling discovery: while patrolling for threats in the gut, some monocytes pick up information that causes them to travel to the spine where they promote inflammation.
"It's as if these monocytes were tricked into over-reacting, thus exacerbating the symptoms of AS," explains Dr. Francesco Ciccia, who led the study with Dr. Haroon.
"Our results suggest that monocytes from the gut could play an important role in AS pathogenesis," says Dr. Haroon. "Moreover, they're providing new insight into the complex relationship between AS and gut inflammation, one factor at a time.
"Our goal is to eventually develop specific drugs to help alleviate the symptoms in these patients."
This work was supported by the Italian Ministero dell'Istruzione, dell'Università e della ricerca Scientifica and the Toronto General & Western Hospital Foundation.