​​​The Sarcoma Site Group is committed to supporting dedicated research positions in basic science, radiotherapy, surgery and medical oncology. Our research focuses on three areas: Patient Information, Advancing Cure and Knowledge Translation.

We currently house the largest Sarcoma Clinical Research Program in Canada at Princess Margaret with five full-time research staff. Through these dedicated researchers and with the support of our patients, we are able to collect data on every sarcoma patient who is referred to our centre. This database captures information about each patient, their tumour and their treatment ranging from diagnosis to long term treatment followup. The patient experience is central to improving standards of care including: how to treat, whom to treat, and identifying patients who would benefit from new directions and innovations in treatment.

The critical "bench to bedside" approach to sarcoma research is key to advancing cure in rare diseases. The availability of rare tumour samples is enormously important in the study of the molecular mechanisms of disease; it supports translational research that will yield more personalized care plans. Thanks to the generosity of patients who have consented to participate in sarcoma genetic research and support our efforts, we currently house an extensive sarcoma surgical biobank at MSH for the benefit of our cross-institution team.

A robust bioinformatics program requires a biobank to link tissue samples to clinical data in a database.

The Sarcoma Site Group at Princess Margaret aims to continually advance the frontiers of our field through clinical and translational research so that we can provide cutting-edge treatment and management in medical, radiation and surgical oncology.​

Find sarcoma clinical trials at the Princess Margaret below, or go to the CanSaRCC website to find sarcoma clinical trials across Canada.

Open Clinical Trials

 
NCT and Other Names
 
Title
 
Principal Investigator
 
Disease Location
Bone
NCT06341712
CLIN-60000-461, 2023-506229-12-00
Effects of Maintenance Cabozantinib+BSC Versus BSC in Children and AYA With OsteosarcomaDr. Abha GuptaBone
NCT06470503
24-5379
EXercise Enhancement After RadioTherapy for Bone MetastasesDr. Michael YanBone
NCT06127407
CL3-95031-007
Ivosidenib in Participants With Locally Advanced or Metastatic Conventional Chondrosarcoma Untreated or Previously Treated With 1 Systemic Treatment RegimenDr. Abdulazeez SalawuBone
Gastrointestinal Stromal (GIST)
NCT05208047
CGT9486-21-301
(Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal TumorsDr. Albiruni RazakGastrointestinal Stromal (GIST)
Multiple Sites
NCT06058793
1403-0019, 2023-504522-19-00
Brightline-4: A Study to Test How Well Brigimadlin is Tolerated by People With a Type of Cancer Called Dedifferentiated LiposarcomaDr. Albiruni RazakMultiple Sites
NCT02811523
15-8820
In Vivo Lung Perfusion for Pulmonary Metastases of SarcomaDr. Marcelo CypelMultiple Sites
Soft Tissue
NCT05269355
PTC596-ONC-008-LMS, 2022-000073-12
A Study of Unesbulin in Participants With Advanced Leiomyosarcoma (LMS)Dr. Abdulazeez SalawuSoft Tissue
NCT06263231
IT-03
A Study to Investigate Efficacy & Safety of Intratumoral INT230-6 Compared to US Standard of Care in Adults With Soft Tissue Sarcomas (INVINCIBLE-3)Dr. Albiruni RazakSoft Tissue
NCT03418818
17-6178
FAZA PET/MRI SarcomaDr. David ShultzSoft Tissue
NCT05950594
23-5436
IVIM & OLINK in SarcomaDr. David ShultzSoft Tissue
NCT06422806
NCI-2023-06412, NCI-2023-06412,EA7222,EA7222,U10CA180820
Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Differentiated SarcomasDr. Abdulazeez SalawuSoft Tissue
NCT02565498
OCREB # 15-070
Preoperative vs Postoperative IMRT for Extremity/Truncal STSDr. Peter ChungSoft Tissue
NCT05804045
ABSK021-301
Study of Pimicotinib (ABSK021) for Tenosynovial Giant Cell Tumor (MANEUVER)Dr. Albiruni RazakSoft Tissue
NCT01344018
EORTC-62092-22092, EORTC-62092,EORTC-22092,EU-21113
Surgery With or Without Radiation Therapy in Untreated Nonmetastatic Retroperitoneal SarcomaDr. Carol SwallowSoft Tissue
 
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To refer a patient to a clinical trial, complete a new patient referral form. Learn more about the Princess Margaret referral process »

For patients: Are you considering taking part in a clinical trial? Learn more about how and why clinical trials are done and what you can expect if you decide to take part in a trial »

https://www.uhn.ca/PrincessMargaret/Education/Continuing_Education_Programs/Pages/continuing_education_programs.aspx
Last reviewed: 10/1/2023
Last modified: 10/30/2023 10:56 AM
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