​​​​​The Princess Margaret Head and Neck Site Group has established itself as a major contributor to local, national and international cancer research initiatives across each of the health care professions that are part of our group.

Key areas of research include clinical trials; translational research; outcomes-based research in medical, radiation and surgical oncology; new drug development; survivorship; quality of life; and supportive care in oncology nursing.

We published the world’s first description of the atypical behaviour of human papillomavirus–related oropharynx cancer compared with typical cancers, as well as a landmark multicentre study that showed the critical impact of radiotherapy protocol compliance and quality in the treatment of advanced head and neck cancer.

In the same year our radiation medicine team produced a mature description of the head and neck anthology of outcomes, which provided the correlative clinical data to accompany biospecimen acquisition in a very successful translational program.

Open Clinical Trials

 
NCT and Other Names
 
Title
 
Principal Investigator
 
Disease Location
Head and Neck
NCT06525220
MCLA-158-CL03, 2023-510323-30-00
A Phase 3 Study to Evaluate Petosemtamab Plus Pembrolizumab vs Pembrolizumab in First-line Treatment of Head and Neck Cancer (LiGeR - HN1)Dr. Anna SpreaficoHead and Neck
NCT06256588
221530, 2023-508613-17
A Study of Dostarlimab vs Placebo After Chemoradiation in Adult Participants With Locally Advanced Unresected Head and Neck Squamous Cell CarcinomaDr. Anna SpreaficoHead and Neck
NCT06064877
AV-299-23-301
A Study of Ficlatuzumab in Combination With Cetuximab in Participants With Recurrent or Metastatic (R/M) HPV Negative Head and Neck Squamous Cell CarcinomaDr. Lillian SiuHead and Neck
NCT05050162
NRG-HN009, NCI-2021-08925,NRG-HN009,NRG-HN009,U10CA180868
Comparing Cisplatin Every Three Weeks to Cisplatin Weekly When Combined With Radiation for Patients With Advanced Head and Neck CancerDr. lawson EngHead and Neck
NCT06487403
24-5510
HN-BIO 02: A Phase II Randomized Study of the Effects of Delayed Elective Radiotherapy on Head and Neck MRI and Immune Response BiomarkersDr. Andrew McPartlinHead and Neck
NCT05919290
22-5864
HN-QUEST: A Study of Head and Neck Imaging BiomarkersDr. Andrew McPartlinHead and Neck
NCT05414032
MERIDIAN
Molecular Residual Disease Interception in Locoregionally-Advanced High Risk HPV+ and HPV- HNSCCDr. Lillian SiuHead and Neck
NCT03455608
CTO1363
PRO-ACTIVE: Prophylactic Swallow Intervention for Patients Receiving Radiotherapy for Head and Neck CancerDr. Rosemary MartinoHead and Neck
NCT02704169
UHN REB 13-5914-C
Quantitative Endoscopy of H&NDr. Jonathan IrishHead and Neck
NCT03765918
3475-689, MK-3475-689,2022-500254-41-00,2017-001139-38
Study of Pembrolizumab Given Prior to Surgery and in Combination With Radiotherapy Given Post-surgery for Advanced Head and Neck Squamous Cell Carcinoma (MK-3475-689)Dr. Anna SpreaficoHead and Neck
NCT05172245
NCI-2021-13901, NCI-2021-13901,10492,10492,UM1CA186644
Testing the Addition of Ipatasertib to Usual Chemotherapy and Radiation for Head and Neck CancerDr. Lillian SiuHead and Neck
Multiple Sites
NCT06062420
219885, 2023-503428-24
A Platform Study of Novel Immunotherapy Combinations as First-Line Treatment in Participants With PD-L1 Positive Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck- GALAXIES H&N-202Dr. Enrique Sanz GarciaMultiple Sites
NCT04040166
18-6313
Carotid PET/MRI With DOTATATE in Patients Post Head and Neck Radiation TherapyDr. Patrick Veit-HaibachMultiple Sites
Nasopharyngeal (NPC)
NCT06457503
CHS-007-01/RTOG 3521
A Study of Toripalimab in Combination With Cisplatin and Gemcitabine in Participants With Recurrent Metastatic Nasopharyngeal CancerDr. Anna SpreaficoNasopharyngeal (NPC)
NCT05166577
VT3996-301
Nanatinostat Plus Valganciclovir in Advanced EBV+ Solid Tumors and in Combination With Pembrolizumab in EBV+ RM-NPCDr. lawson EngNasopharyngeal (NPC)
Oral Cavity
NCT06192771
23-5503
Feasibility of Early Swallowing and Speech Intervention for Head and Neck Cancer Patients Treated SURGicallyDr. Rosemary MartinoOral Cavity
NCT02478138
14-7441
Sentinel Lymph Node Mapping of Oral Cancer Using Near-Infrared Fluorescence ImagingDr. Jonathan IrishOral Cavity
Other
NCT06965738
24-5894
Buccal Fat for Transoral Robotic Lateral Oropharyngectomy Defects to and Postoperative PainDr. Christopher YaoOther
NCT05451004
CCTG-HN11, CCTG-HN11,NCI-2022-04496
SPECT-CT Guided ELEctive Contralateral Neck Treatment for Patients With Lateralized Oropharyngeal CancerDr. Ali Hosni AbdalatyOther
Salivary Glands
NCT02069730
GEMS-001
A Study of Drug Therapies for Salivary Gland Cancers Based on Testing of GenesDr. Anna SpreaficoSalivary Glands
 
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For patients: Are you considering taking part in a clinical trial? Learn more about how and why clinical trials are done and what you can expect if you decide to take part in a trial »

https://www.uhn.ca/PrincessMargaret/Education/Continuing_Education_Programs/Pages/continuing_education_programs.aspx
Last reviewed: 6/9/2025
Last modified: 6/10/2025 10:56 AM
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