​​​​The Breast Site Group at Princess Margaret aims to continuously advance the frontiers of clinical and translational research to provide innovative treatment and management in medical, radiation and surgical oncology. Our key areas of research are clinical trials and drug development, translational research, quality of life and supportive care.

We have a large clinical trials program, ranging from multi-centre Phase III trials to Phase I and II trials, which are led by Breast Site Group members.

Open Clinical Trials

 
NCT and Other Names
 
Title
 
Principal Investigator
 
Disease Location
Breast
NCT06112379
D926QC00001, 2023-505928-59-00
A Phase III Randomised Study to Evaluate Dato-DXd and Durvalumab for Neoadjuvant/Adjuvant Treatment of Triple-Negative or Hormone Receptor-low/HER2-negative Breast CancerDr. David CesconBreast
NCT06103864
D7630C00001
A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast CancerDr. David CesconBreast
NCT05417516
OCOG-2022-RAPID2
A Randomized Trial of Five Fraction Partial Breast Irradiation (RAPID2)Dr. Jennifer CrokeBreast
NCT06312176
2870-010, MK-2870-010,2023-504918-29-00,U1111-1289-8119,jRCT2031240476
A Study of Sacituzumab Tirumotecan (MK-2870) as a Single Agent and in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer (MK-2870-010)Dr. David CesconBreast
NCT06065748
CO44657, 2022-502980-39-00
A Study to Evaluate Efficacy and Safety of Giredestrant Compared With Fulvestrant (Plus a CDK4/6 Inhibitor), in Participants With ER-Positive, HER2-Negative Advanced Breast Cancer Resistant to Adjuvant Endocrine Therapy (pionERA Breast Cancer)Dr. Vikaash KumarBreast
NCT06206837
C4891026, TACTIVE-K,2023-508130-33-00
A Study to Learn About Vepdegestrant When Given With PF-07220060 to People With Advanced or Metastatic Breast Cancer.Dr. David CesconBreast
NCT01837225
10-0633-CE
ALA-induced Fluorescence Imaging of Breast Cancers Using the Handheld PRODIGI and Eagle Imaging DevicesDr. Wey LeongBreast
NCT04397185
BCL IDE
Breast Cancer Locator Guided vs. Wire Localized Partial Mastectomy for Breast CancerDr. Wey LeongBreast
NCT02306538
13-6543C
Evaluation of Myocardial Changes During BReast Adenocarcinoma Therapy to Detect Cardiotoxicity Earlier With MRIDr. Dinesh ThavendiranathanBreast
NCT04228991
OCOG-2019-RHEAL
Hypofractionated LocoRegional Radiotherapy in Breast CancerDr. Kathy HanBreast
NCT06710197
WOO-11-2023
IL-1 Inhibition in Early TNBCDr. Michael ReedijkBreast
NCT05388149
22-5307, KAN-HER2 MRD
Kadcyla And Neratinib for Interception of HER2+ Breast Cancer With Molecular Residual DiseaseDr. David CesconBreast
NCT05601440
I241
Liquid-biopsy Informed Platform Trial to Evaluate CDK4/6-inhibitor Resistant ER+/HER2- Metastatic Breast CancerDr. David CesconBreast
NCT05592938
22-5074
Partial Breast Re-irradiation Using Ultra Hypofractionation (PRESERVE)Dr. Danielle RodinBreast
NCT05812807
A012103, NCI-2022-07859
Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus PembrolizumabDr. David CesconBreast
NCT03564171
041-2018
Prehabilitation for Women Undergoing Pre-operative Chemotherapy for Breast CancerDr. Daniel Santa MinaBreast
NCT04874038
21-5021
Prevention of Persistent Pain With LidocAine iNfusions in Breast Cancer Surgery (PLAN)Dr. Hance ClarkeBreast
NCT04797299
OCOG-2021-ELISA
Prospective Evaluation of Breast-Conserving Surgery Alone in Low-Risk Ductal Carcinoma in Situ (DCIS)Dr. Ezra HahnBreast
NCT03488693
CCTG MA.39, NCI-2017-02047
Regional Radiotherapy in Biomarker Low-Risk Node Positive and T3N0 Breast CancerDr. Christine KochBreast
NCT06393374
2870-012, 2023-504962-52-00,U1111-1289-8264,jRCT2031240476
Sacituzumab Tirumotecan (MK-2870) Plus Pembrolizumab Versus TPC in TNBC Who Did Not Achieve pCR (MK-2870-012)Dr. David CesconBreast
 
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To refer a patient to a clinical trial, complete a new patient referral form. Learn more about the Princess Margaret referral process »

For patients: Are you considering taking part in a clinical trial? Learn more about how and why clinical trials are done and what you can expect if you decide to take part in a trial »

https://www.uhn.ca/PrincessMargaret/Education/Continuing_Education_Programs/Pages/continuing_education_programs.aspx
Last reviewed: 11/5/2024
Last modified: 11/6/2024 5:59 AM
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