Our UHN programs and services are among the most advanced in the world. We have grouped our physicians, staff, services and resources into 10 medical programs to meet the needs of our patients and help us make the most of our resources.
University Health Network is a health care and medical research organization in Toronto, Ontario, Canada. The scope of research and complexity of cases at UHN has made us a national and international source for discovery, education and patient care.
Our 10 medical programs are spread across eight hospital sites – Princess Margaret, Toronto General, Toronto Rehab’s five sites, Toronto Western – as well as our education programs through the Michener Institute of Education at UHN. Learn more about the services, programs and amenities offered at each location.
Maps & Directions
Find out how to get to and around our nine locations — floor plans, parking, public transit, accessibility services, and shuttle information.
Ways You Can Help
Being touched by illness affects us in different ways. Many people want to give back to the community and help others. At UHN, we welcome your contribution and offer different ways you can help so you can find one that suits you.
The Newsroom is the source for media looking for information about UHN or trying to connect with one of our experts for an interview. It’s also the place to find UHN media policies and catch up on our news stories, videos, media releases, podcasts and more.
Toronto (Jan. 9, 2017) – Canadian prostate cancer researchers have discovered the genetic fingerprint that explains why up to 30 per cent of men with potentially curable localized prostate cancer develop aggressive disease that spreads following radiotherapy or surgery.
The findings, published online today in
Nature, could help clinicians personalize effective, targeted therapies from the moment of diagnosis, says co-principal investigator Robert Bristow, clinician-scientist at the Princess Margaret Cancer Centre, University Health Network. Dr. Bristow is also a Professor in the Departments of Radiation Oncology and Medical Biophysics, University of Toronto. He talks about the research in this video.
In the Nature study, Dr. Bristow, co-principal investigator Dr. Paul Boutros from the Ontario Institute for Cancer Research, lead author Dr. Michael Fraser, and collaborators at Laval University in Quebec City, analyzed the tumours of 500 Canadian men in the general population with localized, non-inherited prostate cancer. In a related study also published today, in Nature Communications, Drs. Bristow and Boutros cracked the genetic code to show why BRCA-2 inherited disease turns lethal in rare cases where men have inherited a BRCA2 gene mutation that affects the repair of DNA damage in cells.
"We used specialized state-of-the-art DNA sequencing techniques to focus on the genetics of prostate cancers to better understand what is so different from one man's disease to another man's disease," says Dr. Bristow.
"These genetic fingerprints had high accuracy in being able to discern those men who do well with surgery or radiotherapy and those men that already have early spread of their disease outside the prostate gland. This information gives us new precision about the treatment response of men with prostate cancer, and important clues as to how to better treat one set of men versus the other to improve cure rates overall."
The next step will be to translate this research finding into a molecular diagnostic tool that can be used in the clinic. Dr. Bristow says: "We will be testing 500 more men over the next two to three years to accomplish that. It is an exciting era in prostate cancer research. We will soon be able to identify in the clinic the exact genetic state of a man's cancer and react on a patient-to-patient basis to cure more men worldwide. "
Drs. Bristow and Boutros co-lead the Canadian Prostate Cancer Genome Network (CPC-GENE), the world-leading prostate cancer sequencing program. The research published today builds on their previous published discoveries:
Dr. Bristow says that although most men present with localized, potentially curable disease, more than 200,000 men die of it every year when tallied across all countries.
"The richness of information in our genetic findings today will enable us to further sort individual patients into appropriate groups of risk for spread of their disease and effect cures in men who otherwise might have been incurable."
The research was supported by Movember funds through Prostate Cancer Canada, the Ontario Institute for Cancer Research, the Canadian Institutes for Health Research, the Canadian Cancer Society, and The Princess Margaret Cancer Foundation.
The Princess Margaret Cancer Centre has achieved an international reputation as a global leader in the fight against cancer and delivering personalized cancer medicine. The Princess Margaret, one of the top five international cancer research centres, is a member of the University Health Network, which also includes Toronto General Hospital, Toronto Western Hospital, Toronto Rehabilitation Institute and the Michener Institute for Education; all affiliated with the University of Toronto. For more information, go to www.theprincessmargaret.ca.
Phone: 416 340 4636