Schroeder Arthritis Institute Newsletter December 2020

Celebrating the Launch of the Schroeder Arthritis Institute

The Schroeder Arthritis Institute at UHN

The creation of the Schroeder Arthritis Institute was made possible thanks to a generous $25 million commitment from Walter and Maria Schroeder. The new institute will help UHN’s innovative arthritis program become a world-class hub for innovation in research, education and patient care. The Institute will encompass innovation in research, education and clinical activities within four clinical programs: Hand, Orthopedics, Osteoporosis and Rheumatology, with the core goal of pushing the boundaries of discovery, learning and patient care. The new funds will go toward supporting top scientific talent and providing critical salary and infrastructure resources for the entire research team, which includes 51 scientists and clinician-scientists, 113 trainees and 200 staff. Building on the momentum of the program’s progress in recent years—including innovations in surgical approaches for bone and joint diseases, new diagnostics and treatments in ankylosing spondylitis, lupus, osteoarthritis, osteoporosis, psoriatic arthritis, scleroderma and Sjögren’s syndrome—as well as the development of predictive tools for orthopaedic surgery outcomes, this donation will enable the institute to make a global impact through early diagnosis, innovative treatments and prevention. A special thank you to Walter and Maria Schroeder and to the Toronto General & Western Hospital Foundation for their commitment to helping transform the lives of the one in five Canadian adults living with arthritis.

On December 17, 2020, the Toronto General and Western Hospitals Foundation along with the Schroeder Family, the Co-Directors of the Institute and all staff and trainees came together for a virtual celebration. Click here to view a short video showing the history and potential of the Schroeder Arthritis Institute.

NEW APPOINTMENTS AND PROMOTIONS

Associate Professor

Dr. Anthony Perruccio, Scientist at the Schroeder Arthritis Institute and the Krembil Research Institute, has been promoted to Associate Professor at the IHPME, Dalla Lana School of Public Health and Department of Surgery at the University of Toronto.

Administrative Coordinator

Sheila Mondonedo joins the Schroeder Arthritis Institute as the Administrative Coordinator of the Division of Orthopaedic Surgery.

Clinical Manager of 9A Orthopaedics

Lisa Giraldi joins the Schroeder Arthritis Institute as a permanent full-time Clinical Manager of 9A Orthopaedics. Most recently, Lisa was the Interim Program Services Manager of Outpatient Services at Toronto Rehab, where she assisted all her teams through the pandemic and facilitated virtual rehab models including a COVID rehab stream.

Clinical Nurse Specialist

Janelle Lopez joins the Schroeder Arthritis Institute as a temporary full-time Clinical Nurse Specialist with the Lupus Clinic in the Division of Rheumatology.

AWARDS, GRANTS AND RECOGNITIONS

Canadian Academy of Health Sciences

Dr. Dafna Gladman, a Rheumatologist and a Senior Scientist at the Schroeder Arthritis Institute and the Krembil Research Institute, was elected as a Fellow of the Canadian Academy of Health Sciences. It is a national honour in recognition of her outstanding contribution to the art and science of rheumatology.

American College of Rheumatology and the Arthritis Society Awards

Dr. Anthony Perruccio, Scientist at the Schroeder Arthritis Institute and the Krembil Research Institute, is this year’s American College of Rheumatology (ACR)-Association of Rheumatology Professionals (ARP) Distinguished Scholar Award recipient. Dr. Perruccio was also awarded the Stars Career Development Award. by the Arthritis Society for his work on "Joints and sex – Re-envisioning osteoarthritis".

2020 Lupus Innovation Award

Dr. Zahi Touma, Clinician Investigator and Rheumatologist at the Schroeder Arthritis Institute and the Krembil Research Institute, is one of seven recipients of the 2020 Lupus Innovation Award. Dr. Touma was awarded for his work on "Predicting Cognitive Deficiencies in People with Lupus".

CIHR Project Grant

Principal Investigator Dr. Mohit Kapoor, and Co-Investigators Dr. Rajiv Gandhi, Altum Health Medical Director and Orthopedic Surgeon, and Senior Scientist Dr. Igor Jurisica secured funding through CIHR Project Grant for their project titled “Role and therapeutic potential of MicroRNA-34a-5p in knee osteoarthritis”.

International Research Training

Dr. Andy Wong, Assistant Scientist in the Osteoporosis Program, received the Melbourne-Toronto universities grant which provides funding for 2 PhD candidates whose training would be done in both Toronto and Melbourne.

Tony & Shari Fell Platinum Chair in Arthritis Research

Dr. Mohit Kapoor has been appointed as the inaugural Tony & Shari Fell Platinum Chair in Arthritis Research, a Hospital-University Named Chair, for a five-year term.

University of Toronto 2020-2021 Postgraduate Research Award

Dr. Akihiro Nakamura, a clinical fellow and a PhD candidate supervised by Dr. Nigil Haroon, was awarded the Edward Christie Stevens Fellowships in Medicine and William S. Fenwick Research Fellowship.

Three trainees within the Schroeder Arthritis Institute secured funding through the Arthritis Society. Carolina Munoz-Grajales, a PhD candidate under the Supervision of Dr. Joan Wither, was awarded for her project titled "Characterization of the immunologic events that lead to development of Systemic Autoimmune Rheumatic Disease". Dr. Michelle Barraclough, a postdoctoral fellow who will be working under the supervision of Dr. Zahi Touma, was awarded for her project titled "Cognitive dysfunction and cognitive fatigue in SLE: A pilot study examining the underlying mechanisms with structural and functional MRIs of the brain". Dr. Omar Cruz-Correa, a postdoctoral fellow under the supervision of Dr. Dafna Gladman, was awarded for his project titled "Epigenomic predictors of psoriatic arthritis in patients with psoriasis".

ONLINE INNOVATION

The UHN GLA:D Program is a collaboration between the Division of Orthopedics, Toronto Rehab and Altum Health that offers patients with hip and knee osteoarthritis the GLA:D Program - a structured, evidence based exercise and education program that has been proven to provide meaningful pain management and improvements to daily function and quality of life. This collaborative effort was launched in September 2020. Patients are offered access to the UHN GLA:D Program through the Hip and Knee Rapid Access Clinic (HK RAC), selecting the site of their choice. The program will also be listed on the GLA:D Canada webpage for any patient who would like to access the program. Thank you to Lisa Giraldi (TR), Lisa Caldana (TR) and Charmody Laughton (Altum) for their leadership and collaboration in developing this program and to UHN Senior Leadership – Schroeder Arthritis Institute-Division of Orthopedics, Toronto Rehab and Altum Health for their support.

Arthritis in the News

Check out the latest edition of the Sprott Department of Surgery Magazine, a magazine produced by the Toronto General and Western Hospitals Foundation, to read about the scientists and clinician scientists of the Schroeder Arthritis Institute and the impact their work is having on patients' lives.

Check out this episode of Behind the Breakthrough podcast. Dr. Heather Baltzer from the Hand Program discuses her pioneering treatment of hand trauma.

Check out this episode of Arthritis At Home where Cheryl Koehn has a conversation with Dr. Robert Inman, rheumatologist and senior scientist at the Schroeder Arthritis Institute and the Krembil Research Institute, about the Schroeder Arthritis Institute.

NOTABLE PUBLICATIONS

A bioinformatics approach to microRNA-sequencing analysis

Potla P, Ali SA, Kapoor M. Osteoarthritis and Cartilage. December 2020.
Click here for publication.

Abnormal subgenual anterior cingulate circuitry is unique to women but not men with chronic pain

Osborne NR, Cheng JC, Rogachov A, Kim JA, Hemington KS, Bosma RL, Inman RD, Davis KD. Pain. August 2020.
Click here for publication.

Addition of dexamethasone to local infiltration analgesia in elective total knee arthroplasty: double-blind, randomized control trial

El-Boghdadly K, Short AJ, Gandhi R, Chan V. Regional Anesthesia and Pain Medicine. November 2020.
Click here for publication.

Back pain in surgically treated degenerative lumbar spondylolisthesis: what can we tell our patients?

Bond M, Evaniew N, Bailey CS, Glennie RA, Paquet J, Dea N, Hall H, Manson N, Thomas K, McIntosh G, Soroceanu A, Abraham E, Johnson M, Kingwell S, Charest-Morin R, Christie S, Rampersaud YR, Fisher CG. The Spine Journal. December 2020.
Click here for publication.

Cardio-metabolic effects of long-term treatment with secukinumab in psoriatic arthritis and ankylosing spondylitis patients: Pooled 3 year analysis

McInnes IB, Gladman DD, Deodhar AA, Miceli-Richard C, Nash P, Sattar N, Mehta NN, Wang J, Pricop L, di Comite G. Journal of the American Academy of Dermatology. December 2020.
Click here for publication.

Discordance between self-reported and performance-based function among knee osteoarthritis surgical patients: Variations by sex and obesity

Wilfong JM, Badley EM, Power JD, Gandhi R, Rampersaud YR, Perruccio AV. PloS one. July 2020.
Click here for publication.

Effect of autotaxin inhibition in a surgically-induced mouse model of osteoarthritis

Datta P, Gandhi R, Nakamura S, Lively S, Rossomacha E, Potla P, Shestopaloff K, Endisha H, Pastrello C, Jurisica I, Rockel JS, Kapoor M. Osteoarthritis and Cartilage Open. September 2020.
Click here for publication.

Efficacy of surgical decompression in patients with cervical spondylotic myelopathy results of the Canadian prospective multicenter study

Baile, Christie SD, Paquet J, Nataraj A, Cadotte DW, Wilson J, Manson NA, Hall H, Thomas KC, Rampersaud RY, McIntosh G, Fisher CG, Dea N. The Spine Journal. September 2020.
Click here for publication.

Emergency Department Presentation After Total Hip and Knee Arthroplasty: A Systematic Review

Maldonado-Rodriguez N, Ekhtiari S, Khan MM, Ravi B, Gandhi R, Veillette C, Leroux T. The Journal of Arthroplasty. October 2020.
Click here for publication.

Factors Associated With Return to Work After Surgery for Degenerative Cervical Spondylotic Myelopathy: Cohort Analysis From the Canadian Spine Outcomes and Research Network

Romagna A, Wilson JR, Jacobs WB, Johnson MG, Bailey CS, Christie S, Paquet J, Nataraj A, Cadotte AW, Manson N, Hall H, Thomas KC, Schwartz C, Rampersaud YR, McIntosh G, Fisher CG, Dea N. Global Spine Journal. October 2020.
Click here for publication.

Fibroblasts and their Responses to Chronic Injury in Pulmonary Fibrosis

Wu B, Tang L, Kapoor M. Seminars in Arthritis and Rheumatism. December 2020.
Click here for publication.

Impact of New Motor Deficit on HRQOL after Adult Spinal Deformity Surgery: Subanalysis from Scoli Risk 1 Prospective Study

Saigal R, Lau D, Berven SH, Carreon L, Dekutoski MB, Kebaish KM, Qiu Y, Matsuyama Y, Kelly M, Dahl BT, Mehdian H. Spine. December 2020.
Click here for publication.

Quality Measure Public Reporting Is Associated with Improved Outcomes Following Hip and Knee Replacement

Bozic K, Yu H, Zywiel MG, Li L, Lin Z, Simoes JL, Sheares KD, Grady J, Bernheim SM, Suter LG. The Journal of Bone and Joint Surgery. October 2020.
Click here for publication.

MicroRNA‐34a‐5p Promotes Joint Destruction during Osteoarthritis

Endisha H, Datta P, Sharma A, Nakamura S, Rossomacha E, Younan C, Ali SA, Tavallaee G, Lively S, Potla P, Shestopaloff K, Rockel JS, Krawetz R, Mahomed NN, Jurisica I, Gandhi R, Kapoor M. Arthritis and Rheumatology. October 2020.
Click here for publication.

MicroRNA In Situ Hybridization in Paraffin-Embedded Human Articular Cartilage and Mouse Knee Joints

Endisha H, Kapoor M. Chondrocytes. December 2020.
Click here for publication.

Patient‐reported Disease Activity in an Axial Spondyloarthritis Cohort during the COVID‐19 Pandemic

Liew JW, Castillo M, Zaccagnino E, Katz P, Haroon N, Gensler LS. ACR Open Rheumatology. December 2020.
Click here for publication.

Plastic changes in the brain after human hand allotransplantation

Ni Z, McCabe S, Novak C, Baltzer HL, Jegatheeswaran G, Isayama R, Vesia M, Gunraj C, Saha U, Hallett M, Chen R. Neurology. August 2020.
Click here for publication.

Prediction of hospitalizations in systemic lupus erythematosus using the Systemic Lupus International Collaborating Clinics Frailty Index (SLICC‐FI)

Legge A, Kirkland S, Rockwood K, Andreou P, Bae SC, Gordon C, Romero‐Diaz J, Sanchez‐Guerrero J, Wallace DJ, Bernatsky S, Clarke AE, Merrill JT, Ginzler EM, Fortin PR, Gladman DD, Urowitz MB, Bruce IN, Isenberg DA, Rahman A, Alarcón GS, Petri M, Khamashta MA, Dooley MA, Ramsey‐Goldman R, Manzi S, Zoma AA, Aranow C, Mackay M, Ruiz‐Irastorza G, Lim SS, Inanc M, van Vollenhoven RF, Jonsen A, Nived O, Ramos‐Casals M, Kamen DL, Kalunian KC, Jacobsen S, Peschken CA, Askanase A, Hanly JG. Arthritis Care & Research. November 2020.
Click here for publication.

Preoperative Factors Predict Postoperative Trajectories of Pain and Disability Following Surgery for Degenerative Lumbar Spinal Stenosis

Hébert J, Abraham E, Wedderkopp N, Bigney E, Richardson E, Darling M, Hall H, Fisher CG, Rampersaud YR, Thomas K, Jacobs WB, Johnson M, Paquet J, Attabib N, Jarzem P, Wai E, Rasoulinejad P, Ahn H, Nataraj A, Stratton A, Manson N. Spine. November 2020.
Click here for publication.

Prevalence and factors associated with osteoporosis and bone mineral density testing in psoriatic arthritis

Kwok TSH, Sutton M, Ye JY, Pereira D, Chandran V, Gladman DD. Spine. November 2020.
Click here for publication.

Response to placebo in non-renal, non-neuropsychiatric systemic lupus erythematosus: a systematic review and pooled analysis

Tselios K, Wakani L, Gladman DD, Su J, Urowitz MB. Rheumatology. November 2020.
Click here for publication.

Rho-GTPase pathways may differentiate treatment response to TNF-alpha and IL-17A inhibitors in psoriatic arthritis

Rahmati S, O’Rielly DD, Li Q, Codner D, Dohey A, Jenkins K, Jurisica I, Gladman DD, Chandran V, Rahman P. Scientific Reports. December 2020.
Click here for publication.

Sex-differences in brain modular organization in chronic pain

Fauchon C, Meunier D, Rogachov A, Hemington KS, Cheng JC, Bosma RL, Osborne NR, Kim JA, Inman RD, Davis KD. Pain. October 2020.
Click here for publication.

Stemless anatomic total shoulder arthroplasty: a systematic review and meta-analysis

Liu EY, Kord D, Horner NS, Leroux T, Alolabi B, Khan M. Journal of Shoulder and Elbow Surgery. September 2020.
Click here for publication.

The Effect of Perioperative Adverse Events on Long-Term Patient-Reported Outcomes After Lumbar Spine Surgery

Ayling OG, Ailon T, Street JT, Dea N, McIntosh G, Abraham E, Jacobs WB, Soroceanu A, Johnson MG, Paquet J, Rasoulinejad P, Phan P, Yee A, Christie S, Nataraj A, Glennie RA, Hall H, Manson, N, Rampersaud YR, Thomas K, Fisher CG. Neurosurgery. October 2020.
Click here for publication.

Union of Foot/Ankle Arthrodesis: A Registry Study of Low-Intensity Pulsed Ultrasound (LIPUS)

White NJ, Lau JT, Ong K, Kurtz SM, Lin SS. Foot & Ankle Orthopaedics. November 2020.
Click here for publication.

What Goes Bump in the Night: An Evaluation of Emergency Department Visits Following Total Joint Arthroplasty

Maldonado-Rodriguez N, Gandhi R, Sundararajan K, Rampersaud YR, Mahomed N, Leroux TS. The Journal of Arthroplasty. November 2020.
Click here for publication.

Year in review: genetics, genomics, epigenetics

Ratneswaran A, Kapoor M. Osteoarthritis and Cartilage. November 2020.
Click here for publication.

Zinc finger protein-440 promotes cartilage degenerative mechanisms in human facet and knee osteoarthritis chondrocytes

Nakamura A, Rampersaud YR, Sundararajan K, Nakamura S, Wu B, Matip E, Haroon N, Krawetz RJ, Rossomacha E, Gandhi R, Kotlyar M, Rockel JS, Jurisica I, Kapoor M. Osteoarthritis and Cartilage. December 2020.
Click here for publication.