Our UHN programs and services are among the most advanced in the world. We have grouped our physicians, staff, services and resources into 10 medical programs to meet the needs of our patients and help us make the most of our resources.
University Health Network is a health care and medical research organization in Toronto, Ontario, Canada. The scope of research and complexity of cases at UHN has made us a national and international source for discovery, education and patient care.
Our 10 medical programs are spread across eight hospital sites – Princess Margaret, Toronto General, Toronto Rehab’s five sites, Toronto Western – as well as our education programs through the Michener Institute of Education at UHN. Learn more about the services, programs and amenities offered at each location.
Maps & Directions
Find out how to get to and around our nine locations — floor plans, parking, public transit, accessibility services, and shuttle information.
Ways You Can Help
Being touched by illness affects us in different ways. Many people want to give back to the community and help others. At UHN, we welcome your contribution and offer different ways you can help so you can find one that suits you.
The Newsroom is the source for media looking for information about UHN or trying to connect with one of our experts for an interview. It’s also the place to find UHN media policies and catch up on our news stories, videos, media releases, podcasts and more.
Regeneration of the blood system through the transplantation of blood-forming stem cells (commonly referred to as a bone marrow transplantation) is an effective treatment for a range of blood cell diseases, including leukemia. Additionally, the transplantation of blood-forming stem cells and specific blood cell types is already in the clinic or under investigation for the treatment of an expanded list of diseases, such as other cancers, autoimmune diseases and inflammation. Currently, cells for these therapies are obtained from immune-matched donors or from the patients themselves. Although effective, reliance on donor and patient-derived cells limits the number of patients that can be treated and benefit from these transplantation-based therapies. The generation of blood-forming stem cells and specific blood cell types from human pluripotent stem cells (hPSCs) would provide a new and potentially unlimited supply of these cells for treating a much broader patient population.
Using insights from blood cell development in different organisms, the Keller lab has successfully modeled human hematopoietic development from hPSCs differentiated in vitro. Through manipulation of specific signaling pathways they demonstrated that it is possible to generate the two major hematopoietic programs, primitive and definitive, which are known to develop in the embryo. While the main function of primitive hematopoiesis is to generate the cohort of blood cells required to sustain embryonic life, recent studies have shown that this program also contributes to a specialized immune cell population, the tissue-resident macrophage that persists in different organs into adulthood. These macrophages are thought to play important roles in maintaining normal organ function. Definitive hematopoiesis gives rise to all of the hematopoietic cell types found in the adult, including the hematopoietic stem cell (HSC). Through our ability to specify these two programs, we have been able to develop protocols for the generation of most of the hematopoietic cells found in the embryo as well as in the adult. Additionally, we have been able to identify developmentally-staged progenitors that display the properties of the progenitors that give rise to the HSC in the embryo. These advances have brought us an important step closer to generating hPSC-derived HSCs, immune cells and tissue-resident macrophages for the development new cell-based therapies to treat different diseases.
Current projects include: