ALERT CONTENT PLACEHOLDER

​​​​Projects and published studies that have requested support from the Peter Munk Cardiac Centre Cardiovascular Biobank.

​​​Learn more about our Biobank
​​

 


Study Title:
Aortic Valve Replacement with Pulmonary Autograft
Study Team:
Dr. Tirone David (Principal Investigator), Dr. Maral Ouzounian (Co-Investigator)

Study Title:
MicroRNA Examination of Heart Failure Patient Phenotypes
Study Team:
Dr. Jason Fish (Principal Investigator), Dr. Phyllis Billia (Co-Investigator), Dr. David Cherney (Co-Investigator), Dr. Ren-Ke Li (Co-Investigator)

Study Title:
Biomarkers in the Trajectory of Cancer Therapy Related Cardiac Dysfunction
Study Team:
Dr. Paaladinesh Thavendiranathan (Principal Investigator), Dr. Liran Shlush (Co-Investigator), Dr. Eitan Amir (Co-Investigator), Dr. Phyllis Billia (Co-Investigator), Dr. Jason Fish (Co-Investigator)

Study Title:
Brugada Syndrome: Serum Biomarker Study

Study Team:
Dr. Dana Spears (Principal Investigator), Dr. Robert Hamilton (Co-Investigator)

Study Title:
Novel Therapeutic Targets and Potential Biomarkers: Identifying Extracellular Vesicle-Derived MicroRNA Governing Human Abdominal Aortic Aneurysm Progression
Study Team:
Dr. Kathryn Howe (Principal Investigator), Dr. Jason Fish (Co-Investigator), Dr. Alison Fox-Robichaud (Co-Investigator), Dr. John Harlock (Co-Investigator), Dakota Gustafson (Co-Investigator), Dr. Bo Wang (Co-Investigator), Dr. Thomas Forbes (Co-Investigator)

Study Title:
Characterizing Heart and Mind Health Post-Chemotherapy in Women with Breast Cancer
Study Team:
Dr. Husam Abdel-Qadir (Principal Investigator), Dr. Dr. Eitan Amir (Co-Investigator), Dr. Christine Brezden-Masley (Co-Investigator), Dr. Kim Connelly (Co-Investigator), Dr. Pamela Goodwin (Co-Investigator), Dr. Gillian Nesbitt (Co-Investigator), Dr. Darryl Leong (Co-Investigator), Dr. Sukhbinder Dhesy-Thind (Co-Investigator), Dr. Katarzyna Jerzak (Co-Investigator), Dr. Shaheeda Ahmed (Co-Investigator), Dr. Josee-Lyne Ethier (Co-Investigator), Dr. Raveen Pal (Co-Investigator), Dr. Ian Paterson (Co-Investigator), Dr. Kibar Yared (Co-Investigator), Dr. Iliana Lega (Co-Investigator), Dr. Lorraine Lipscombe (Co-Investigator), Dr. Peter Austin (Co-Investigator), Dr. Douglas Lee (Co-Investigator), Dr. Patrick Lawler (Co-Investigator), Dr. Peter Juni (Co-Investigator), Karen Pope (Co-Investigator), Dr. Paaladinesh Thavendiranathan (Co-Investigator)

Study Title:
Thoracic Aortic Genomic Study
Study Team:
Dr. Maral Ouzounian (Principal Investigator), Dr. Jennifer Chung (Co-Investigator), Dr. John Parkinson (Co-Investigator), Dr. Raymond Kim (Co-Investigator)

Study Title:
Clinical outcomes after aortic valve sparing operations
Study Team:
Dr. Tirone David (Principal Investigator), Dr. Christopher Feindel (Co-Investigator), Dr. Maral Ouzounian (Co-Investigator)

Study Title:
C-Type Natriuretic Peptide Signaling in Aortic Valve Disease ValveCNP
Study Team:
Dr. Terrence Yau (Principal Investigator), Rachel Adams (Co-Investigator), Dr. Craig Simmons (Co-Investigator), Dr. Robert James Cusimano (Co-Investigator), Dr. Jagdish Butany (Co-Investigator), Dr. Maral Ouzounian (Co-Investigator), Dr. Phyllis Billia (Co-Investigator), Dr. Richard Weisel (Co-Investigator)

Study Title:
Canadian Outcomes Registry Late After Tetralogy of Fallot Repair: the CORRELATE study
Study Team:
Dr. Rachel Wald (Principal Investigator), Dr. Christopher Caldarone (Co-Investigator), Dr. Nagib Dahdah (Co-Investigator), Dr. Frederic Dallaire (Co-Investigator), Dr. Christian Drolet (Co-Investigator), Dr. Jasmine Grewal (Co-Investigator), Dr. Edward Hickey (Co-Investigator), Dr. Michelle Keir (Co-Investigator), Dr. Paul Khairy (Co-Investigator), Dr. Adrienne Kovas (Co-Investigator), Dr. Gerald Lebovic (Co-Investigator), Dr. Benedetta Leonardi (Co-Investigator), Dr. Brian McCrindle (Co-Investigator), Dr. Syed Najaf Nadeem (Co-Investigator), Dr. Ming-Yen Ng (Co-Investigator), Dr. Erwin Oechslin (Co-Investigator), Dr. Andrew Redington (Co-Investigator), Dr. Ashish Shah (Co-Investigator), Dr. Candice Silversides (Co-Investigator), Dr. Edythe Tham (Co-Investigator), Dr. Judith Therrien (Co-Investigator), Dr. Alexander Van De Bruaene (Co-Investigator), Dr. Isabelle Vonder Muhll (Co-Investigator), Dr. Andrew Warren (Co-Investigator), Dr. Bernd Wintersperger (Co-Investigator), Dr. Michael Farkouh (Co-Investigator)

Study Title:
Biology of Vascular Carotid Lesions
Study Team:
Dr. Jason Fish (Principal Investigator), Dr. Kathryn Howe (Co-Investigator), Dr. Alison Fox-Robichaud (Co-Investigator), Dr. John Harlock (Co-Investigator), Dakota Gustafson (Co-Investigator), Dr. Bo Wang (Co-Investigator), Dr. Thomas Forbes (Co-Investigator)

Study Title:
Strain Surveillance during Chemotherapy for Improving Cardiovascular Outcomes

Study Team:
Dr. Tom Marwick (Principal Investigator), Dr. Paaladinesh Thavendiranathan (Co-Investigator), Dr. Frederic Poulin (Co-Investigator), Dr. Martin Penicka (Co-Investigator), Dr. Krassimira Hristova (Co-Investigator), Dr. Satoshi Yuda (Co-Investigator), Dr. Bogdan Popescu (Co-Investigator), Dr. Dragos Vinereanu (Co-Investigator), Dr. John Atherton (Co-Investigator), Dr. Tony Stanton (Co-Investigator), Dr. John Horowitz (Co-Investigator), Dr. Walter Abhayaratna (Co-Investigator), Prof Jens-Uwe Voigt (Co-Investigator), Prof Patricio Lancellotti (Co-Investigator), Dr. Agnes Pasquet (Co-Investigator), Prof Frank Weidemann (Co-Investigator), Prof. Andreas Hagendorff (Co-Investigator), Stephan von Bardeleben (Co-Investigator), Luigi Badano (Co-Investigator), Dr. JW Ha (Co-Investigator), Dr. Goo Yeong Cho (Co-Investigator), Dr. Jae-Kwan Song (Co-Investigator), Dr. Svend Aakhus (Co-Investigator), Prof Pepe Zamorano (Co-Investigator)

Study Title:
Evaluation of Myocardial Changes during Breast Adenocarcinoma Therapy to Detect Cardiotoxicity Earlier with MRI

Study Team:
Dr. Paaladinesh Thavendiranathan (Principal Investigator), Dr. Philippe Bedard (Co-Investigator), Dr. Amit M Oza (Co-Investigator), Dr. Bernd Wintersperger (Co-Investigator)

Study Title:
Arrhythmogenic Right Ventricular Cardiomyopathy Serum Biomarker Study

Study Team:
Dr. Danna Spears (Principal Investigator), Dr. Robert Hamilton (Co-Investigator)

Study Title:
Recurrent Myocarditis After Fulminant Myocarditis Induced by Immune-Checkpoint Inhibitor Treatment

Study Team:
Dr. Diego Delgado (Principal Investigator), Dr. Nazanin Aghel (Co-Investigator), Dakota Gustafson (Co-Investigator), Milena Music (Co-Investigator), Dr. Jagdish Butany (Co-Investigator), Dr. Aaron Hansen (Co-Investigator), Dr. Eleftherios P. Diamandis (Co-Investigator), Dr. Javid Moslehi (Co-Investigator), Dr. Paaladinesh Thavendiranathan (Co-Investigator), Dr. Jason Fish (Co-Investigator)

Study Title:
Cardiac Genome Project: a collaborative model for identifying genetic basis of heart failure in the whole-genome era

Study Team:
Dr. Raymond Kim (Principal Investigator), Dr. Rachel Wald (Co-Investigator), Dr. Heather Ross (Co-Investigator), Dr. Phyllis Billia (Co-Investigator), Dr. Michael Gollob (Co-Investigator), Melanie Care (Co-Investigator), Josh Silver (Co-Investigator), Dr. Arnon Adler (Co-Investigator), Dr. Harry Rakowski (Co-Investigator), Dr. Carolina Alba (Co-Investigator), Dr. Vijay S. Chauhan (Co-Investigator), Dr. Erwin Oechslin (Co-Investigator), Dr. Maral Ouzounian (Co-Investigator), Dr. Danna Spears (Co-Investigator), Dr. Candice Silversides (Co-Investigator), Dr. Hannaneh Faghfoury (Co-Investigator), Dr. Chantal Morel (Co-Investigator), Jillian Murphy (Co-Investigator), Dr. Joyce So (Co-Investigator)

Study Title:
Novel clinical, molecular and –omics approaches to prediction of heart failure readmission

Study Team:
Dr. Douglas Lee (Principal Investigator), Dr. Slava Epelman (Co-Investigator), Dr. Patrick Lawler (Co-Investigator), Dr. Heather Ross (Co-Investigator), Dr. Anthony Gramolini (Co-Investigator)

Study Title:
Study of genomics, proteomics and metabolomics for identification of pathophysiological pathways in hypertrophic cardiomyopathy

Study Team:
Dr. Arnon Adler (Principal Investigator), Dr. Manhal Habib (Co-Investigator), Dr. Raymond Kim (Co-Investigator)

Study Title:
Development of a platform for ex vivo heart perfusion

Study Team:
Dr. Phyllis Billia (Principal Investigator), Dr. Mitesh Badiwala (Co-Investigator), Dr. Vivek Rao (Co-Investigator), Dr. Juglans Alvarez (Co-Investigator)

Study Title:
Discovering the inflammatory and metabolic signature in patients with progressive heart failure

Study Team:
Dr. Phyllis Billia (Principal Investigator), Dr. Patrick Lawler (Co-Investigator), Dr. Adriana Luk (Co-Investigator), Dr. John E. Dick (Co-Investigator), Dr. Anthony Gramolini (Co-Investigator), Dr. Heather Ross (Co-Investigator)

Study Title:
The effect of central versus peripheral acting drugs used in heart failure on respiratory drive

Study Team:
Dr. Phyllis Billia (Principal Investigator), Dr. Carolina Alba (Co-Investigator), Dr. Cedric Manhliot (Co-Investigator), Farid Faroutan (Co-Investigator), Dr. Melissa Allwood (Co-Investigator)

Study Title:
Genetic Research in Hypertrophic Cardiomyopathy

Study Team:
Dr. Harry Rakowski (Principal Investigator), Dr. Arnon Adler (Co-Investigator), Dr. Raymond Kim (Co-Investigator)

Study Title:
Randomized double blind placebo controlled trial of Statins for the Primary Prevention of Heart Failure in patients with cancer receiving anthracycline based chemotherapy

Study Team:
Dr. Paaladinesh Thavendiranathan (Principal Investigator), Dr. Eitan Amir (Co-Investigator)

Wu J., Song HF., Guo J., Tsang K., Tumiati L., Butany J., Yau TM., Ouzounian M., Fu S., David TE., Weisel RD., Li RK. Progressive aortic dilation is regulated by miR-17-associated miRNAs​. J Am Coll Cardiol. 2016 Jun 28; 67(25): 2965-77. doi: 10.1016/j.jacc.2016.04.027.

Zhang Y., Xie B., Sun L., Chen W., Jiang SL., Liu W., Bian F., Tian H., Li RK. Phenotypic switching of vascular smooth muscle cells in the ‘normal region’ of aorta from atherosclerosis patients is regulated by miR-145​. J Cell Mol Med. 2016 Jun; 20(6): 1049-61. doi: 10.1111/jcmm.12825.

Dadson K., Hauck L., Hao Z., Grothe D., Rao V., Mak TW., Billia F. The E3 ligase Mule protects the heart against oxidative stress and mitochondrial dysfunction through Myc-dependent inactivation of Pgc-1α and Pink1. Nat Sci Rep. 2017 Feb 2; 7: 41490. doi: 10.1038/srep41490.

Hauck L., Stanley-Hasnain S., Fung A., Grothe D., Rao V., Mak TW., Billia F. Cardiac-specific ablation of the E3 ubiquitin ligase Mdm2 leads to oxidative stress, broad mitochondrial deficiency and early death​. PLoS One​. 2017 Dec 21; 12(12): e0189861. doi: 10.1371/journal.pone.0189861.