Dr. Mohit Kapoor and his team have discovered one of the processes responsible for inflammation.
Osteoarthritis (OA) is characterized by the erosion of joint cartilage (the tough elastic material that protects the ends of bones). This damage is caused by inflammation, which can lead to joint stiffness and swelling that can be debilitating. The mechanisms responsible for joint inflammation and cartilage destruction in OA are not fully known; however, a recent study led by Arthritis Program Scientist, Dr. Mohit Kapoor, has revealed one of the processes responsible.
In a study published in the Annals of Rheumatic Diseases, Dr. Kapoor and his team used an experimental model of osteoarthritis. They discovered that PPARD – a factor that governs genes that respond to inflammation and joint destruction – is critical to keep the disease under control. When PPARD function was lost, joint inflammation and cartilage destruction increased. These two effects, when combined, accelerated the progression and severity of osteoarthritis.
This study suggests that medications capable of promoting PPARD function may be effective for osteoarthritis. These anti-inflammatory drugs are already approved for treating diseases like diabetes. As such, they represent an accessible option for improving the quality of life for people with OA.