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Research Opportunities at the Memory Clinic

The Ontario Neurodegenerative Disease Research Initiative (ONDRI)

Investigator: Dr. Carmela Tartaglia

We are conducting a province wide observational study on people with mild cognitive impairment (MCI). The study is looking for links between cognitive disturbances and a number of other features (brain imaging (MRI), eye movements and eye retina changes, gait analysis and blood tests including genetic studies in MCI and several other brain disorders including : AD, PD, FTD, VCI, and ALS.

The aim of the study is a better understanding of cognitive disturbances and related features, and hopefully lead to improved treatments.

The study consists of yearly visits for 3 years and a telephone assessment at 6 months. The assessments would involve: MRI, Blood test, Neuropsychology testing (memory and attention), Gait assessment, and ocular testing.

You will be reimbursed for transportation and parking expenses.

For further information, please contact Dr. Carmela Tartaglia at 416 603 5483.

A Double-Blind, Placebo-Controlled, Randomized, Parallel Group, 12-Month Safety and Efficacy Trial of Leuco-methylthioninium bis(hydromethanesulfonate) in Subjects with Behavioral Variant Frontotemporal Dementia (bvFTD) (Study TRx-237-007)

Investigator: Dr. Carmela Tartaglia

Behavioral variant FTD (bvFTD) is a type of dementia characterized by early and slow changes in personality, loss of emotion and/or loss of empathy. Patients experience difficulty in controlling behaviour, and this often results in socially inappropriate responses or activities. Issues with language may also occur after behavioural changes have become notable. Currently, there is no cure for FTD.

We are currently seeking participant and their carer's, who may wish to take part in our clinical trial (research study) of a potential new treatment for behavioural variant Frontotemporal Dementia.

The study will require 10 visits to the clinic over a period of approximately 60 weeks

You will be reimbursed for transportation and parking expenses.

For further information, please contact Dr. Carmela Tartaglia at 416 603 5483.

Assessing changes in social cognition and personality in patients with Parkinson's disease, Alzheimer's disease and Frontotemporal Dementia, and their effect on the patient-caregiver relationship

Investigator: Dr. Carmela Tartaglia

Alzheimer's disease is associated with cognitive impairments but can also be associates with changes in social cognition and personality. Social cognition involves thoughts and brain processes that we use to understand and to interact with the people around us. It is hypothesized that some of these changes may also affect the quality of the patient-caregiver relationship.

For this study, patients and their caregiver will be required to fill out several questionnaires and watch videos. In addition, patients will undergo an MRI scan.

You will be reimbursed for transportation and parking expenses.

For further information, please contact Dr. Carmela Tartaglia at 416 603 5483.

Assessing the benefits of an outpatient aerobic activity program in patients with Alzheimer's disease

Investigator: Dr. Carmela Tartaglia

The aim of this study is to compare cognitive function, behavioural symptoms, caregiver burden and brain structure and function between patients who engage in an outpatient aerobic activity program for 6 months and those that do not. Understanding the effects of aerobic activity in patients with Alzheimer's disease may help provide better care to patients with Alzheimer's disease.

Participation would involve coming in for 3hours per week for 6 months.

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You will be reimbursed for transportation and parking expenses.

For further information, please contact Dr. Carmela Tartaglia at 416 603 5483.​