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Donors make major breakthrough possible

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Donors make major breakthrough possible
Dr. Mohit Kapoor, Dr. Raja Rampersaud, and Dr. Akihiro Nakamura
​​​​​L - R: Dr. Mohit Kapoor, senior scientist, Dr. Raja Rampersaud, clinical expert and spine surgeon, and Dr. Akihiro Nakamura, post-doctoral fellow collaborated on this world-first discovery.

Philanthropic investments made by grateful patients to the Campaign to Cure Arthritis have leveraged a world first discovery. A research team at the Krembil Research Institute has discovered a pair of tissue biomarkers that directly contribute to the harmful joint degeneration associated with spine osteoarthritis. This study, published recently in the Journal of Clinical Investigation Insight, is the first to show that elevated levels of both of these biomarkers cause inflammation, cartilage destruction and collagen depletion.​

“These biomarkers are actively involved in increasing inflammation and destructive activities in spine cartilage and assist in its destruction,” says principal investigator Dr. Mohit Kapoor, Senior Scientist at the Krembil Research Institute who specializes in arthritis research.